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Showing 1–20 of 20 results
Advanced filters: Author: Susan Bonner-Weir Clear advanced filters

  • Although pancreatic islet transplantation can restore normal β-cell function to patients with diabetes, success is limited by tissue availability. An alternative strategy is to stimulate development of the patients' own β cells; however, the postnatal origin of new β cells remains controversial. This Viewpoint proposes that progenitor cells could exist in the pancreatic ducts.

    • Susan Bonner-Weir
    • Arun Sharma
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 240-241

  • Clinicians and patients with type 1 diabetes mellitus eagerly await the successful use of stem cell-derived β cells in clinical practice. This Review provides a summary of current strategies to obtain cells which express insulin from different progenitor sources and highlights the main pathways and genes involved, as well as the different approaches for the modulation of the immune response in patients with type 1 diabetes mellitus.

    • Cristina Aguayo-Mazzucato
    • Susan Bonner-Weir
    Reviews
    Nature Reviews Endocrinology
    Volume: 6, P: 139-148

  • Two analyses of insulin-producing β-cells reveal differences in what has long been considered a homogeneous population. These differences might reflect changes during maturation or ageing, or distinct cell lineages. See Letter p.430

    • Susan Bonner-Weir
    • Cristina Aguayo-Mazzucato
    News & Views
    Nature
    Volume: 535, P: 365-366

  • Bariatric surgery to treat obesity can also be effective against type 2 diabetes, but it is unclear how such surgical procedures improve glucose metabolism. A new study in rats suggests that nutrient sensing in the jejunum contributes to the antidiabetic effects of duodenal-jejeunal bypass (pages 950–955).

    • David A Sarruf
    • Susan Bonner-Weir
    • Michael W Schwartz
    News & Views
    Nature Medicine
    Volume: 18, P: 860-861

  • Three separate labs report that p16INK4a, a protein known to be expressed in an age-dependent manner regulates ageing specifically in stem cells. Studying its role in regeneration of three different tissues, the blood, pancreas, and brain, the three groups separately found that p16INK4a is not only a biomarker, but an effector of ageing.

    • Janakiraman Krishnamurthy
    • Matthew R. Ramsey
    • Norman E. Sharpless
    Research
    Nature
    Volume: 443, P: 453-457

  • In a recent issue of Cell Reports, Xi et al. reported on their studies of an anti-glucagon receptor antibody in several mouse models of insulin-deficient diabetes mellitus, in which they show substantial increase in β-cell mass from enhanced replication and transdifferentiation of glucagon-expressing α-cells to insulin-expressing β-cells.

    • Maria F. Rubin de Celis
    • Susan Bonner-Weir
    News & Views
    Nature Reviews Endocrinology
    Volume: 18, P: 659-660

  • Pancreatic islets, which are critical for glucose homeostasis, are endocrine microorgans embedded in the exocrine pancreas; their location has often limited studying their function. In 2019, advances in islet biology were achieved with new technologies extending findings from several decades ago and with conceptual advances built on findings from other fields.

    • Susan Bonner-Weir
    News & Views
    Nature Reviews Endocrinology
    Volume: 16, P: 73-74

  • Transplantation of pancreatic islet cells could provide a cure for diabetes. However, it has been difficult to obtain sufficient numbers of purified islets from a single cadaver pancreas. Stem cell technology may someday overcome this limitation, and may also make possible the use of autologous tissues (278–282).

    • David H. Sachs
    • Susan Bonner-Weir
    News & Views
    Nature Medicine
    Volume: 6, P: 250-251

  • The adult mouse pancreas contains precursor cells able to differentiate toward both pancreatic and neural lineages.

    • Gordon C Weir
    • Susan Bonner-Weir
    News & Views
    Nature Biotechnology
    Volume: 22, P: 1095-1096