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Showing 1–2 of 2 results
Advanced filters: Author: Susan Realegeno Clear advanced filters

  • BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.

    • Helena Escuin-Ordinas
    • Shuoran Li
    • Antoni Ribas
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, rendering macrophages susceptible to bacterial infection.

    • Bryan D. Bryson
    • Tracy R. Rosebrock
    • Sarah M. Fortune
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11