Mutations in PINK1 cause early-onset Parkinson’s disease. Martins and colleagues find that the expression levels of genes involved in nucleotide metabolism are upregulated in a Drosophila pink1 mutant, and that this affects neuronal mitochondrial DNA synthesis. They find that enhancing nucleotide synthesis through genetics or pharmacological approaches rescues mitochondrial defects associated with PINK1 mutations.
- Roberta Tufi
- Sonia Gandhi
- L. Miguel Martins
