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Showing 1–2 of 2 results
Advanced filters: Author: Susanna Monroe Clear advanced filters

  • Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.

    • Hideko Isozaki
    • Ramin Sakhtemani
    • Aaron N. Hata
    Research
    Nature
    Volume: 620, P: 393-401

  • A risk haplotype for type 2 diabetes is identified with four amino acid substitutions in SLC16A11, which is present at ∼50% frequency in Native American samples and ∼10% in east Asian samples, but is rare in European and African samples; SLC16A11 may alter hepatic lipid metabolism, causing an increase in triacylglycerol levels.

    • Amy L. Williams
    • Suzanne B. R. Jacobs
    • Teresa Tusié-Luna
    Research
    Nature
    Volume: 506, P: 97-101