Stromal progenitor cells contribute to the maintenance of tissue homeostasis in different organs. In vitro, these mesenchymal stromal cells (MSCs) can differentiate into many cell types. Recent omics and single-cell studies provide insights into the gene regulatory networks that drive lineage determination and cell differentiation, which has implications for the understanding of human diseases and for the development of cell-based therapies.
- Alexander Rauch
- Susanne Mandrup
