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Showing 1–4 of 4 results
Advanced filters: Author: Susanne Zabel Clear advanced filters

  • The mechanisms behind CO2 dependency in non-autotrophic bacterial isolates are unclear. Here the authors show that the Staphylococcus aureus mpsAB operon is crucial for growth at atmospheric CO2 levels, and provide evidence indicating that MpsAB represents a bicarbonate concentrating system.

    • Sook-Ha Fan
    • Patrick Ebner
    • Friedrich Götz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • A series of FRET-based β-arrestin2 biosensors are used to study the dynamics and conformational changes that occur when β-arrestin2 binds to and dissociates from the β2-adrenergic receptor in living cells; results show that after β-arrestin2 dissociates from the β2-adrenergic receptor, it stays at the cell membrane in an active conformation for a while, indicating that β-arrestin is able to signal in a G-protein-coupled receptor (GPCR)-free state.

    • Susanne Nuber
    • Ulrike Zabel
    • Carsten Hoffmann
    Research
    Nature
    Volume: 531, P: 661-664

  • Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.

    • Angela Tomasovic
    • Theresa Brand
    • Kristina Lorenz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Arif Luqman et al. demonstrate that trace amines accelerate wound healing by antagonizing β2-adrenergic receptor whose activation inhibits cell motility. This study suggests that trace amine-producing Staphylococcus epidermidis strains present on human skin may play a beneficial role for wound healing.

    • Arif Luqman
    • Muhammad Zainul Muttaqin
    • Friedrich Götz
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-10