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Showing 1–9 of 9 results
Advanced filters: Author: Sussan Nourshargh Clear advanced filters

  • During sterile inflammation, emigrating leukocytes sequentially engage subsets of pericytes associated with blood vessels and acquire adhesive, migratory and survival signals.

    • Ronen Alon
    • Sussan Nourshargh
    News & Views
    Nature Immunology
    Volume: 14, P: 14-15

  • The blood vessel wall is a complex multi-layered structure, yet upon injury or infection, neutrophil leukocytes are rapidly migrating from the blood stream to the affected tissues, by a process termed diapedesis. Authors here show that the final steps of diapedesis through the outer pericyte layer is regulated by perivascular mast cells via IL-17A production.

    • Régis Joulia
    • Idaira María Guerrero-Fonseca
    • Mathieu-Benoit Voisin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Leukocytes use different strategies to migrate through the endothelium of venular walls and in interstitial tissues. These strategies are regulated by soluble and cell-bound signals. Studies have identified many of the cellular and subcellular events that govern transendothelial migration and are beginning to elucidate the nature of leukocyte interstitial motility.

    • Sussan Nourshargh
    • Peter L. Hordijk
    • Michael Sixt
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 366-378

  • A key consequence of increased and sustained vascular permeability in several inflammatory and cardiovascular disorders is the development of interstitial protein-rich proinflammatory edema. This response remains poorly understood mechanistically and its potential adverse effect on local and systemic diseases is often underestimated. To discuss current findings and identify crucial unresolved questions, a workshop was held in Berlin from 12–15 April 2023. Key topics that were discussed included regulation of endothelial cell junctions, neutrophil-dependent vascular leakage, resolution of edema, exemplar diseases, and anti-edema therapies. This report is a summary of the meeting.

    • Dietmar Vestweber
    • Lena Claesson-Welsh
    • Michael Simons
    News & Views
    Nature Cardiovascular Research
    Volume: 2, P: 1120-1124

  • To get to the site of inflammation, leukocytes must first adhere to and traverse the blood-vessel wall, events that occur in a cascade-like manner. But what are the exact steps in this cascade and what molecules are involved?

    • Klaus Ley
    • Carlo Laudanna
    • Sussan Nourshargh
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 678-689

  • Here, the authors discuss recent evidence indicating that components of the immune system are under the control of circadian rhythms. The circadian oscillations of immune mediators may allow the host to anticipate threats more efficiently but may also contribute to circadian exacerbations of chronic diseases. In addition, these circadian rhythms should be considered in the design of preclinical animal models, when harvesting human tissue samples and in vaccine administration.

    • Christoph Scheiermann
    • Yuya Kunisaki
    • Paul S. Frenette
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 190-198