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Showing 1–7 of 7 results
Advanced filters: Author: Suwannee Thet Clear advanced filters

  • The neonatal heart has a high regenerative capacity that is lost in adult life; the transcription factor Meis1 has been identified as a relevant proliferative switch for this transition, providing a potential therapeutic target for adult heart regeneration.

    • Ahmed I. Mahmoud
    • Fatih Kocabas
    • Hesham A. Sadek
    Research
    Nature
    Volume: 497, P: 249-253

  • Lam et al. show that conditional deletion of calcineurin B1 in cardiomyocytes and its inhibition using the US Food and Drug Administration-approved drug, FK506, promotes cardiomyocyte cell-cycle re-entry and increases cardiomyocyte numbers in adult mice

    • Nicholas T. Lam
    • Ngoc Uyen Nhi Nguyen
    • Hesham A. Sadek
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 679-688

  • Ahmed, Nguyen et al. show that two FDA-approved antibiotics, paromomycin and neomycin, promote cardiomyocyte proliferation and improve cardiac function after myocardial infarction in mice and pigs by interfering with the cell division inhibiting function of transcription factors Meis1 and Hoxb13.

    • Mahmoud Salama Ahmed
    • Ngoc Uyen Nhi Nguyen
    • Hesham A. Sadek
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 372-388

  • Hoxb13 acts as a cofactor of Meis1 in regulating cardiomyocyte maturation and cell cycle, and knockout of both proteins enables regeneration of postnatal cardiac tissue in a mouse model of heart injury.

    • Ngoc Uyen Nhi Nguyen
    • Diana C. Canseco
    • Hesham A. Sadek
    Research
    Nature
    Volume: 582, P: 271-276

  • A pathway triggered by chronic severe hypoxia boosts regeneration of injured hearts in adult mice.

    • Yuji Nakada
    • Diana C. Canseco
    • Hesham A. Sadek
    Research
    Nature
    Volume: 541, P: 222-227

  • Fate-mapping hypoxic cells in the mouse heart identifies a rare population of cycling cardiomyocytes, which show characteristics of neonatal cardiomyocytes, including smaller size and mononucleation, and contribute to new cardiomyocyte formation in the adult heart.

    • Wataru Kimura
    • Feng Xiao
    • Hesham A. Sadek
    Research
    Nature
    Volume: 523, P: 226-230