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Showing 1–3 of 3 results
Advanced filters: Author: Suzel Davanture Clear advanced filters
  • De Palma and colleagues develop a dendritic cell therapy based on dendritic cell progenitors engineered to produce IL-12 and FLT3L and show antigen-agnostic reduction of tumor burden that can be exploited for combination therapy in glioma.

    • Ali Ghasemi
    • Amaia Martinez-Usatorre
    • Michele De Palma
    ResearchOpen Access
    Nature Cancer
    Volume: 5, P: 240-261
  • Bernier-Latmani et al. report a mechanism for maintaining colon cancer-associated vasculature, in which colon endothelial apelin signaling promotes migration of distant venous endothelial cells toward the tumor progenitor cell niche to sustain VEGFA-independent vascular expansion and a normoxic microenvironment.

    • Jeremiah Bernier-Latmani
    • Christophe Cisarovsky
    • Tatiana V. Petrova
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 476-490
  • The molecular mechanisms ensuring the specialized structure of small intestinal villus tip blood vessels are incompletely understood. Here the authors show that ADAMTS18+ telocytes maintain a “just-right” level and location of VEGFA signaling on intestinal villus blood vessels, thereby ensuring the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.

    • Jeremiah Bernier-Latmani
    • Cristina Mauri
    • Tatiana V. Petrova
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17