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Communications Biology (1)

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Distinct conformational states enable transglutaminase 2 to promote cancer cell survival versus cell death

A structural study of the protein crosslinking enzyme tissue transglutaminase (TG2), combining time-resolved SAXS and cryo-EM approaches, details the mechanisms by which TG2 responds to activating calcium ions or to a small-molecule inhibitor.

Cody Aplin
Kara A. Zielinski
Shawn K. Milano
ResearchOpen Access13 Aug 2024
Communications Biology

Volume: 7, P: 1-16

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Distinct conformational states enable transglutaminase 2 to promote cancer cell survival versus cell death

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