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Showing 1–13 of 13 results
Advanced filters: Author: Sven Enerbäck Clear advanced filters

  • Brown fat is a thermogenically active organ that burns energy instead of storing it and has been the focus of intense research recently in the hopes of harnessing this activity to combat obesity. Sven Enerbäck and his colleagues now show that human neonates possess a classical form of this type of fat, suggesting hope that its expansion in adults may indeed be an avenue of therapy to treat obesity.

    • Martin E Lidell
    • Matthias J Betz
    • Sven Enerbäck
    Research
    Nature Medicine
    Volume: 19, P: 631-634

  • 2012 has been a rewarding year for adipocyte research. A new type of brown-like adipocyte—the beige adipocyte—and irisin, a previously unknown hormone that stimulates the formation of such cells, have been discovered. A bipotential adipocyte progenitor giving rise to both brown and white adipocytes has also been identified.

    • Sven Enerbäck
    News & Views
    Nature Reviews Endocrinology
    Volume: 9, P: 69-70

  • Targeting thermogenesis in brown fat and skeletal muscle to expend energy and reduce fat mass is a promising therapeutic strategy for treating obesity and related metabolic diseases. Here, Betz and Enerbäck discuss the different molecular pathways regulating thermogenesis in these organs and discuss how they can be therapeutically exploited.

    • Matthias J. Betz
    • Sven Enerbäck
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 77-87

  • Several independent studies have shown the presence of functional brown adipose tissue in adult humans. Its innate ability to expend energy via heat production is a feature that could be used to develop new regimens to treat obesity and type 2 diabetes mellitus. This Review outlines the current knowledge on the transcriptional regulation and development of brown adipose tissue and addresses possible targets that may be useful for the expansion and/or activation of brown adipose tissue by pharmacological means.

    • Martin E. Lidell
    • Sven Enerbäck
    Reviews
    Nature Reviews Endocrinology
    Volume: 6, P: 319-325

  • Enerbäck and Rabinowitz summarize emerging evidence that lactate serves as a universal circulating fuel for mammalian cells.

    • Joshua D. Rabinowitz
    • Sven Enerbäck
    Reviews
    Nature Metabolism
    Volume: 2, P: 566-571

  • Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.

    • Katarina Klepac
    • Ana Kilić
    • Alexander Pfeifer
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.

    • Masaji Sakaguchi
    • Weikang Cai
    • C. Ronald Kahn
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The Forkhead transcription factors FOXK1 and FOXK2, which are induced by starvation, reprogram cellular metabolism to induce aerobic glycolysis.

    • Valentina Sukonina
    • Haixia Ma
    • Sven Enerbäck
    Research
    Nature
    Volume: 566, P: 279-283

  • Cold exposure activates brown adipose tissue (BAT) through the sympathetic nervous system, and previous studies have reported inhibitory effects of the purinergic transmitter adenosine in BAT from hamster or rat; here adenosine/A2A signalling is shown to be involved in sympathetic activation of human and murine brown adipocytes to allow protection of mice from diet-induced obesity.

    • Thorsten Gnad
    • Saskia Scheibler
    • Alexander Pfeifer
    Research
    Nature
    Volume: 516, P: 395-399