Karposi’s Sarcoma-associated herpesvirus (KSHV) infection is associated with malignancy in older infected humans. Here the authors characterise antigen presentation using a KSHV-specific CD4+ T cell-derived TCR in a mouse model and show that although KSHV-specific CD4+ T cells are difficult to detect in humans, antigen presentation is effective in vivo suggesting persistence and accumulation of these cells through antigen recognition.
- Michelle Böni
- Shitao Peng
- Christian Münz
