Nature Search

Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk

In this study, the authors develop a flavivirus vaccine strategy by introducing mutations into envelope glycoproteins resulting in structural changes that conceal the ADE-prone fusion loop epitope. They show that the Zika virus-specific construct protects mice against viral challenge and prevents ADE by Dengue virus.

Yimeng Wang
Andrey Galkin
Yuxing Li
ResearchOpen Access22 Dec 2025
Nature Communications

Volume: 16, P: 1-22
Potent neutralization of Marburg virus by a vaccine-elicited antibody

A newly developed monoclonal antibody, MARV16, broadly neutralizes all Marburg virus isolates and provides effective protection in guinea pigs with Marburg virus disease.

Amin Addetia
Lisa Perruzza
David Veesler
ResearchOpen Access12 Nov 2025
Nature

P: 1-11
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

The beta variant (B.1.351) is to date the most resistant to neutralization of the SARS-CoV-2 variants. Using nonhuman primates, Seder and colleagues demonstrate that double vaccination with a high dose of the lipid nanoparticle vaccine mRNA-1273 protects against infection with the beta variant.

Kizzmekia S. Corbett
Anne P. Werner
Robert A. Seder
Research20 Aug 2021
Nature Immunology

Volume: 22, P: 1306-1315
Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

Lisa H. Tostanoski
Abishek Chandrashekar
Dan H. Barouch
ResearchOpen Access10 Jan 2022
npj Vaccines

Volume: 7, P: 1-6
Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands

Mahasweta Chatterjee
Sharmistha Saha
Kanchan Mukhopadhyay
ResearchOpen Access02 Nov 2022
Scientific Reports

Volume: 12, P: 1-9
Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

Chiuppesi et al. demonstrate that COVID-19 vaccine COH04S1, harboring a synthetic modified vaccinia Ankara-vector, elicits cross-reactive responses against mpox virus (MPXV) similar to those induced by FDA-approved mpox vaccine JYNNEOS in healthy adults and non-human primates. COH04S1 also confers protective immunity against MPXV in a mouse model of mpox.

Flavia Chiuppesi
John A. Zaia
Don J. Diamond
ResearchOpen Access16 Feb 2024
Communications Medicine

Volume: 4, P: 1-9
Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters

Berry, Pavot et al. test a vaccine with sequences of the spike protein of the Beta and ancestral variants to overcome immune escape by new SARS-CoV-2 variants. They show in animal models the vaccine successfully expands the breadth and duration of antibody neutralization of several variants and offers protection to some variants.

Catherine Berry
Vincent Pavot
Valerie Lecouturier
ResearchOpen Access26 May 2023
Communications Medicine

Volume: 3, P: 1-16
Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants

Felix Wussow
Mindy Kha
Don J. Diamond
ResearchOpen Access16 Mar 2023
npj Vaccines

Volume: 8, P: 1-9
Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Mariana F. Tioni
Robert Jordan
Roderick S. Tang
ResearchOpen Access29 Jul 2022
npj Vaccines

Volume: 7, P: 1-13
Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

Flavia Chiuppesi
Vu H. Nguyen
Don J. Diamond
ResearchOpen Access21 Jan 2022
npj Vaccines

Volume: 7, P: 1-14
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Kathryn McGuckin Wuertz
Erica K. Barkei
Kayvon Modjarrad
ResearchOpen Access28 Oct 2021
npj Vaccines

Volume: 6, P: 1-11

Search

Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk

Potent neutralization of Marburg virus by a vaccine-elicited antibody

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands

Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters

Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

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