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Showing 1–4 of 4 results
Advanced filters: Author: Swathi V. Iyer Clear advanced filters

  • The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma.

    • Swathi V. Iyer
    • Atul Ranjan
    • Tomoo Iwakuma
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Gboxin and its chemical derivatives inhibit the growth of primary human and mouse glioblastoma cells, but not of mouse embryonic fibroblasts or neonatal astrocytes, by targeting mitochondrial oxidative phosphorylation complexes.

    • Yufeng Shi
    • S. Kyun Lim
    • Luis F. Parada
    Research
    Nature
    Volume: 567, P: 341-346

  • Iwakuma and colleagues report that statins, through their action on the mevalonate pathway, lead to the ubiquitin-mediated degradation of misfolded mutant p53 by impairing its interaction with the Hsp40 family member, DNAJA1.

    • Alejandro Parrales
    • Atul Ranjan
    • Tomoo Iwakuma
    Research
    Nature Cell Biology
    Volume: 18, P: 1233-1243