Fibrosis of the skin and other organs is a key feature of systemic sclerosis (SSc). Studies performed during the past decade have provided a more detailed insight to the cellular and immune mechanisms underlying the fibrotic process in SSc. In this Review, the authors describe these important recent findings, and how our improved understanding of SSc fibrosis has facilitated the development of potential targeted therapies.
- Swati Bhattacharyya
- Jun Wei
- John Varga
