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Showing 1–6 of 6 results
Advanced filters: Author: Swati Krishnan Clear advanced filters

  • Artificial DNA membrane channels are promising molecular devices for biotechnology but suffer from low affinity for lipid bilayers. Here, the authors report a large DNA nanopore that spontaneously inserts into a flat lipid membrane, driven by engineered hydrophobic or streptavidin-biotin interactions.

    • Swati Krishnan
    • Daniela Ziegler
    • Friedrich C. Simmel
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • Innate immune cells such as dendritic cells and macrophages can activate the adaptive immune system against cancer by presenting cancer-specific antigens, although this activity is severely limited in macrophages due to their intrinsic lysosomal cysteine protease activity. Here the authors show that a DNA nanodevice specifically targeted to macrophage lysosomes can inhibit cysteine proteases in these cells, restoring their antigen-presenting capability.

    • Chang Cui
    • Kasturi Chakraborty
    • Lev Becker
    Research
    Nature Nanotechnology
    Volume: 16, P: 1394-1402

  • DNA self-assembly has previously been used to create channel-like structures that can penetrate through lipid bilayer membranes. However, such assemblies have not been shown to cause cell death before. Now a DNA nanopore has been shown to exert a cytotoxic effect when administered to cells.

    • Swati Krishnan
    • Friedrich C. Simmel
    News & Views
    Nature Chemistry
    Volume: 7, P: 17-18

  • Single-cell RNA-seq could help identify acute myeloid leukaemia (AML) patients at high risk of relapse after therapy. Here, the authors use single-cell RNA-seq from paediatric AML samples to construct a 7-gene signature that can identify malignant cells at diagnosis, which are distinctly associated with relapse or complete remission.

    • Hope Mumme
    • Beena E. Thomas
    • Manoj Bhasin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Artificial nanopores can perform selective gating of molecules analogous to transmembrane proteins. Here, the authors design a DNA origami pore with a controllable lid for size-selective gating and translocation of macromolecules and evaluate its biosensing properties by single particle assay.

    • Rasmus P. Thomsen
    • Mette Galsgaard Malle
    • Jørgen Kjems
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10