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Showing 1–3 of 3 results
Advanced filters: Author: Syed Zahed Rasheed Clear advanced filters

  • South Asia is home to almost 2 billion people but is extremely underrepresented in human genetics. This study uses genomes from ~5,000 South Asians to characterize genetic variation and help facilitate future South Asian genetic studies.

    • Jeffrey D. Wall
    • J. Fah Sathirapongsasuti
    • Andrew S. Peterson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Danish Saleheen, Benjamin Voight and colleagues perform genome-wide analysis of multi-ancestry cohorts to identify genetic associations with type 2 diabetes (T2D) and coronary heart disease (CHD). They find novel loci and show that 24% of T2D loci are also associated with CHD and that greater genetic risk of T2D increases risk of CHD.

    • Wei Zhao
    • Asif Rasheed
    • Danish Saleheen
    Research
    Nature Genetics
    Volume: 49, P: 1450-1457

  • By sequencing the exomes of 10,503 individuals living in Pakistan, the authors identify rare predicted loss-of-function mutations that are estimated to knock out genes and correlate these mutations with a broad range of phenotypes, providing a framework for a human knockout project.

    • Danish Saleheen
    • Pradeep Natarajan
    • Sekar Kathiresan
    Research
    Nature
    Volume: 544, P: 235-239