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Showing 1–6 of 6 results
Advanced filters: Author: Sylvain Fourmaux Clear advanced filters

  • Current short-pulse-duration neutron sources suffer from a low repetition rate, hindering applications. Here, the authors demonstrate advancements of laser-wakefield based photoneutron generation at high repetition rates and conversion efficiencies, providing an alternative to traditional pitcher-catcher methods.

    • Simon Vallières
    • François Fillion-Gourdeau
    • Steve MacLean
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Laser-plasma electron accelerators are ultracompact and come with an embedded betatron X-ray source with small source size and ultrashort pulse length. The authors combine the edge illumination-beam tracking technique with a compact plasma X-ray source and present a demonstration of multimodal imaging down to the femtosecond timescale.

    • Adam Doherty
    • Sylvain Fourmaux
    • Silvia Cipiccia
    ResearchOpen Access
    Communications Physics
    Volume: 6, P: 1-8

  • Microsatellite instability (MSI) due to alterations in DNA repair genes leads to carcinogenesis, but it also correlates with better prognosis and therapy response. Little is known of the contribution of altered noncoding sequences to MSI tumorigenesis. This report identifies a deletion in an MSI intronic region leading to the expression of a truncated chaperone, which shows dominant-negative effects on its wild-type counterpart. Acting as an endogenous inhibitor of a protumorigenic chaperone, the expression of the truncated variant associates with better prognosis in humans and may contribute to the overall limited malignancy of MSI tumors.

    • Coralie Dorard
    • Aurélie de Thonel
    • Alex Duval
    Research
    Nature Medicine
    Volume: 17, P: 1283-1289