Nature Search

Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes

In 653,790 individuals, this multi-ancestral meta-analysis of tobacco use disorder finds 461 potential risk genes and hundreds of associations with health outcomes, showcasing the utility of electronic health records for genetic research.

Sylvanus Toikumo
Mariela V. Jennings
Sandra Sanchez-Roige
Research17 Apr 2024
Nature Human Behaviour

Volume: 8, P: 1177-1193
SLC45A4 is a pain gene encoding a neuronal polyamine transporter

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Steven J. Middleton
Sigurbjörn Markússon
David L. Bennett
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 404-412
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

Gray et al. find that the genetic overlap between alcohol use disorder and body mass index consists of variants with mixed directions of effect and implicates brain regions involved in executive functioning, reward and food intake regulation.

Samantha G. Malone
Christal N. Davis
Joshua C. Gray
Research31 Mar 2025
Nature Human Behaviour

Volume: 9, P: 1056-1066
Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans

Sylvanus Toikumo
Rachel Vickers-Smith
Henry R. Kranzler
Amendments and Corrections07 May 2024
Nature Medicine

Volume: 30, P: 2088
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

A multi-ancestry genome-wide association study of problematic alcohol use in one million individuals identified 110 risk variants and shows that multi-ancestry polygenic scores improve risk prediction compared with single-ancestry scores

Hang Zhou
Rachel L. Kember
Joel Gelernter
ResearchOpen Access07 Dec 2023
Nature Medicine

Volume: 29, P: 3184-3192
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction

This genome-wide association study identified 12 novel loci for opioid use disorder, a common, potentially fatal condition. Analyses implicated the CNS, with gene expression enriched in brain regions associated with addiction.

Rachel L. Kember
Rachel Vickers-Smith
Henry R. Kranzler
Research28 Sept 2022
Nature Neuroscience

Volume: 25, P: 1279-1287
A multi-ancestry genetic study of pain intensity in 598,339 veterans

A cross-ancestry meta-analysis identified 126 genetic loci associated with chronic pain intensity, revealing correlations with substance use and psychiatric traits.

Sylvanus Toikumo
Rachel Vickers-Smith
Henry R. Kranzler
Research01 Mar 2024
Nature Medicine

Volume: 30, P: 1075-1084
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens

Benjamin C. Reiner
Samar N. Chehimi
Richard C. Crist
ResearchOpen Access06 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Youshu Cheng
Cecilia Dao
Ke Xu
ResearchOpen Access05 May 2023
Translational Psychiatry

Volume: 13, P: 1-9
Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits

Sylvanus Toikumo
Heng Xu
Henry R. Kranzler
Research08 Aug 2022
Neuropsychopharmacology

Volume: 47, P: 2292-2299
Genome-wide differentially methylated genes associated with posttraumatic stress disorder and longitudinal change in methylation in rape survivors

Jani Nöthling
Naeemah Abrahams
Sian Megan Joanna Hemmings
ResearchOpen Access19 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-21

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes

SLC45A4 is a pain gene encoding a neuronal polyamine transporter

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction

A multi-ancestry genetic study of pain intensity in 598,339 veterans

A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits

Genome-wide differentially methylated genes associated with posttraumatic stress disorder and longitudinal change in methylation in rape survivors

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