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Showing 1–2 of 2 results
Advanced filters: Author: Syuuhei Komatsu Clear advanced filters

  • Thermoresponsive degradable copolymers and hydrogels were synthesized by radical copolymerization of 2-methylene-1,3-dioxepane (MDO) and N,N-dimethylacrylamide (DMAAm). These prepared materials showed thermoresponsive property through the balance of hydrophobic MDO and hydrophilic DMAAm in the polymer chain. Under alkaline conditions (pH 11.3), these materials degraded and turned into water-soluble oligomers. In addition, the hydrogels self-degraded in PBS due to the decreased pH of the inner hydrogel. The prepared thermoresponsive degradable hydrogels are expected as stimuli-responsive drug delivery carriers and cell culture scaffolds.

    • Syuuhei Komatsu
    • Takuya Sato
    • Akihiko Kikuchi
    Research
    Polymer Journal
    Volume: 53, P: 731-739

  • Using a facile method, a gelatin hydrogel with anisotropic gel properties was prepared on a substrate via hydrogelation to induce self-assembly. Three kinds of surface properties (structural control factors) of the template induce the formation of an anisotropic gelatin network by self-assembly. The swelling behavior and mechanical properties of the anisotropic and isotropic gelatin hydrogels are different. When the hydrogel is compressed in a direction perpendicular to the tube-like gelatin network, the inner space of the network is compressed.

    • Kohei Kawaguchi
    • Syuuhei Komatsu
    • Kazuki Murai
    Research
    Polymer Journal
    Volume: 54, P: 377-383