Memories can be reconsolidated when reactivated. However, reconsolidation does not occur under certain boundary conditions. The authors show that these boundary conditions can be transient and that strong auditory fear memories in rats that initially did not undergo reconsolidation eventually did over time. Moreover, they find that the hippocampus is necessary for preventing reconsolidation from occuring in the amygdala, and that NR2B subunits, normally required for induction of reconsolidation in the amygdala, are downregulated when strong memories do not undergo reconsolidation.
- Szu-Han Wang
- Lucas de Oliveira Alvares
- Karim Nader
