Nature Search

Smartphone language features may help identify adverse post-traumatic neuropsychiatric sequelae and their trajectories

Lisa Vizer
Jennifer Pierce
Xinming An
ResearchOpen Access20 May 2025
NPP—Digital Psychiatry and Neuroscience

Volume: 3, P: 1-10
NINJ1 mediates plasma membrane rupture during lytic cell death

The small transmembrane protein NINJ1 promotes plasma membrane rupture in lytic cell death associated with pyroptosis, necrosis and apoptosis.

Nobuhiko Kayagaki
Opher S. Kornfeld
Vishva M. Dixit
Research20 Jan 2021
Nature

Volume: 591, P: 131-136
Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine

Modified nucleosides are often used in mRNA vaccines and can affect protein expression and immunogenicity. Here, the authors compare M segment based Andes virus mRNA vaccines, either with regular uridine or N1-methylpseudouridine, and characterize immune response and protection in rodents.

Ivan V. Kuzmin
Ruben Soto Acosta
Alexander Bukreyev
ResearchOpen Access30 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Mechanisms and therapeutic implications of hypermutation in gliomas

Temozolomide therapy seems to lead to mismatch repair deficiency and hypermutation in gliomas, but not to an increase in response to immunotherapy.

Mehdi Touat
Yvonne Y. Li
Keith L. Ligon
Research15 Apr 2020
Nature

Volume: 580, P: 517-523
Complete protein sequence and identification of structural domains of human apolipoprotein B

T. J. Knott
R. J. Pease
J. Scott
Research23 Oct 1986
Nature

Volume: 323, P: 734-738
Monitor changes to ice-bound nuclear fallout in Antarctica

Krystyna M. Saunders
Karina T. Meredith
Correspondence18 Jul 2023
Nature

Volume: 619, P: 465
De novo design of knotted tandem repeat proteins

This study reports the successful de novo design of a trefoil knotted protein fold for which the crystal structure agrees closely with the intended trefoil knot topology.

Lindsey A. Doyle
Brittany Takushi
Philip Bradley
ResearchOpen Access24 Oct 2023
Nature Communications

Volume: 14, P: 1-17
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.

Sonja I Berndt
Christine F Skibola
Susan L Slager
Research16 Jun 2013
Nature Genetics

Volume: 45, P: 868-876
Melanoma genome sequencing reveals frequent PREX2 mutations

Whole-genome sequencing of 25 metastatic melanomas and matched germline DNA in humans reveals that the highest mutation load is associated with chronic sun exposure, and that the PREX2 gene is mutated in approximately 14 per cent of cases

Michael F. Berger
Eran Hodis
Levi A. Garraway
ResearchOpen Access09 May 2012
Nature

Volume: 485, P: 502-506
Initial sequencing and comparative analysis of the mouse genome

Asif T. Chinwalla
Lisa L. Cook
Michael C. Zody
Research05 Dec 2002
Nature

Volume: 420, P: 520-562
Photo-tautomerization of acetaldehyde as a photochemical source of formic acid in the troposphere

The concentration of formic acid in Earth’s atmosphere is under-predicted by atmospheric models. Here the authors show that acetaldehyde photo-tautomerizes to vinyl alcohol under tropospheric conditions, with subsequent oxidation via OH radicals supplying up to 60% of total modeled formic acid production over oceans.

Miranda F. Shaw
Bálint Sztáray
Scott H. Kable
ResearchOpen Access03 Jul 2018
Nature Communications

Volume: 9, P: 1-7
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a non-Hodgkin-type B cell lymphoma. Here, the authors identify two risk loci for WM/LPL in a two-stage GWAS involving a family-oversampling approach and provide evidence for a functional role of the non-coding SNP rs116446171.

Mary L. McMaster
Sonja I. Berndt
Neil E. Caporaso
ResearchOpen Access10 Oct 2018
Nature Communications

Volume: 9, P: 1-12
Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100

Chao-Yuh Yang
San-Hwan Chen
Lawrence Chan
Research23 Oct 1986
Nature

Volume: 323, P: 738-742
Clinical outcomes of de novo metastatic HER2-positive inflammatory breast cancer

Ana C. Garrido-Castro
Meredith M. Regan
Filipa Lynce
ResearchOpen Access02 Jun 2023
npj Breast Cancer

Volume: 9, P: 1-6
Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity

Cognitive abilities change with age, but why some decline and some do not is not clear. Here, the authors use data from the Cam-CAN cohort to show that distributed, multi-component brain responsivity and default-mode deactivation supports and characterizes preserved cognition across the adult lifespan.

Dávid Samu
Karen L. Campbell
Lorraine K. Tyler
ResearchOpen Access08 May 2017
Nature Communications

Volume: 8, P: 1-14
Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

Neural processing speed slows with age, but the relationship between this slowing and brain atrophy is unknown. Here, authors show that age-related functional brain differences in auditory and visual processing are partly due to structural differences in the distinct brain regions underlying these processes.

D. Price
L. K. Tyler
R. N. A. Henson
ResearchOpen Access09 Jun 2017
Nature Communications

Volume: 8, P: 1-12
Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

The antigen-presenting abilities of plasmacytoid dendritic cells (DCs) are not well characterized. Villadangos and colleagues show that unlike conventional DCs, plasmacytoid DCs continue to synthesize and degrade MHC class II molecules, and thereby present endogenous viral antigen, after activation.

Louise J Young
Nicholas S Wilson
Jose A Villadangos
Research12 Oct 2008
Nature Immunology

Volume: 9, P: 1244-1252
A comparative study on karyotypic diversification rate in mammals

P A Martinez
U P Jacobina
C J Bidau
Research02 Nov 2016
Heredity

Volume: 118, P: 366-373
A microengineered vascularized bleeding model that integrates the principal components of hemostasis

Hemostasis is a complex ensemble of events, but current bleeding assays only analyze single components like coagulation or platelet function. Here the authors present a comprehensive vascularized microfluidic mechanical injury bleeding model that addresses different aspects of the hemostatic process.

Yumiko Sakurai
Elaissa T. Hardy
Wilbur A. Lam
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-9
Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule-associated protein Ase1 for spindle bipolarity.

Sergio A. Rincon
Adam Lamson
Phong T. Tran
ResearchOpen Access17 May 2017
Nature Communications

Volume: 8, P: 1-12
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

Alison P. Klein
Brian M. Wolpin
Laufey T. Amundadottir
ResearchOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Deep vein thrombosis in spinal cord injury: effect of prophylaxis with calf compression, aspirin,and dipyridamole

David Green
Ennio C Rossi
Stewart M Spies
Research01 Aug 1982
Spinal Cord

Volume: 20, P: 227-234
Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP

Timothy H T Cheng
Maggie Gorman
Ian Tomlinson
ResearchOpen Access07 May 2014
European Journal of Human Genetics

Volume: 23, P: 260-263
Analysis of the nucleolar organizing regions in the ant Tapinoma nigerrimum (Hymenoptera, Formicidae)

P Lorite
A E Aránega
T Palomeque
Research01 Jun 1997
Heredity

Volume: 78, P: 578-582
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

IL-23 is needed to protect mucosal surfaces from bacterial pathogens. Murphy and colleagues identify a Notch-2-dependent CD11b⁺ dendritic cell population that produces IL-23 and is required for survival after infection with Citrobacter.

Ansuman T Satpathy
Carlos G Briseño
Kenneth M Murphy
Research04 Aug 2013
Nature Immunology

Volume: 14, P: 937-948
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.

Chao Wang
Li Fan
Li Gan
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-19
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved.

Meredith L. Jenkins
Jean Piero Margaria
John E. Burke
ResearchOpen Access14 Sept 2018
Nature Communications

Volume: 9, P: 1-13
Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

Elizabeth M. Simpson
Carol C. Linder
John J. Sharp
Research01 May 1997
Nature Genetics

Volume: 16, P: 19-27
2019 M7.1 Ridgecrest earthquake slip distribution controlled by fault geometry inherited from Independence dike swarm

Faults responsible for the 2019 M7.1 Ridgecrest, California earthquake likely evolved through reactivation of pre-existing Independence dike swarm structures. The inherited rupture geometry strongly controlled the earthquake slip distribution.

Johanna M. Nevitt
Benjamin A. Brooks
Brad T. Aagaard
ResearchOpen Access20 Mar 2023
Nature Communications

Volume: 14, P: 1-12
The Worth of Science

T. LL. H.
News17 Jan 1931
Nature

Volume: 127, P: 81-82
Management of viral retinitis-associated retinal detachment in AIDS

D Hannouche
J F Korobelnik
T Hoang-Xuan
Research01 Jan 1997
Eye

Volume: 11, P: 33-36
Diffuse Alveolar Damage in the Evolution of Bronchopulmonary Dysplasia in the Baboon

J J Coalson
T J Kuehl
R A DeLemos
Research01 Sept 1988
Pediatric Research

Volume: 24, P: 357-366
Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Alterations of locus coeruleus signal intensity have been associated with functional changes in health and disease. Here, the authors tested a pre-registered hypothesis on a large number of subjects as part of the Cam-CAN consortium.

Kathy Y. Liu
Rogier A. Kievit
Dorothea Hämmerer
ResearchOpen Access06 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Reproductive characters of interspecific hybrids between Trifolium repens L. and T. nigrescens Viv.

A H Marshall
T P T Michaelson-Yeates
M Meredith
Research01 Feb 1995
Heredity

Volume: 74, P: 136-145
Dissolution of pseudophakic fibrinous exudate with intraocular streptokinase

Paul B Mullaney
David T Wheeler
Talal Al-Nahdi
Research01 May 1996
Eye

Volume: 10, P: 362-366
Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer

The role of keratinocyte subpopulations in the different phases of the viral cycle during HPV16 infection remains to be characterised. Here, single cell RNA sequencing of HPV16 infected and uninfected organoids identifies 12 distinct keratinocyte populations including an HPV-reprogrammed keratinocyte subpopulation that is linked to cancer.

Mary C. Bedard
Tafadzwa Chihanga
Susanne I. Wells
ResearchOpen Access08 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging

Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorphic effect on the heart.

Chung-Yang Yeh
Lucas C. S. Chini
Dudley W. Lamming
Research27 Nov 2024
Nature Aging

Volume: 4, P: 1760-1771
Science and Art at the Royal Academy, 1945

A. T. HOPWOOD
News09 Jun 1945
Nature

Volume: 155, P: 687-688
Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

JoAnne McLaurin
Meredith E Kierstead
Peter St George-Hyslop
Research11 Jun 2006
Nature Medicine

Volume: 12, P: 801-808
Local potassium signaling couples neuronal activity to vasodilation in the brain

Jessica A Filosa
Adrian D Bonev
Mark T Nelson
Research01 Oct 2006
Nature Neuroscience

Volume: 9, P: 1397-1403
Unraveling the functional dark matter through global metagenomics

A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.

Georgios A. Pavlopoulos
Fotis A. Baltoumas
Nikos C. Kyrpides
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 594-602
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

In a new study including 200 families who experienced perinatal death, adding genomic analyses to standard autopsies improved the identification of underlying pathogenic causes and informed genetic counseling.

Alicia B. Byrne
Peer Arts
Hamish S. Scott
ResearchOpen Access19 Jan 2023
Nature Medicine

Volume: 29, P: 180-189
Ventilatory Management of Infant Baboons with Hyaline Membrane Disease: The Use of High Frequency Ventilation¹

R A Delemos
J J Coalson
T J Kuehl
Research01 Jun 1987
Pediatric Research

Volume: 21, P: 594-602
One-way membrane trafficking of SOS in receptor-triggered Ras activation

Analyses in supported lipid bilayers and in cells shed light on the roles of multiple SOS-membrane interactions in SOS's membrane recruitment and association, processive activation of Ras and signal attenuation.

Sune M Christensen
Hsiung-Lin Tu
Jay T Groves
Research08 Aug 2016
Nature Structural & Molecular Biology

Volume: 23, P: 838-846
Elevated Verbal IQ and Idiopathic Precocious Sexual Maturation

J Money
T Meredith
Research01 Jan 1967
Pediatric Research

Volume: 1, P: 59-65
Coccolith dissolution within copepod guts affects fecal pellet density and sinking rate

Meredith M. White
Jesica D. Waller
David M. Fields
ResearchOpen Access27 Jun 2018
Scientific Reports

Volume: 8, P: 1-6
Cancer related information that cancer patients need

K. Osowiecka
M. Rucińska
A. Hagihara
ResearchOpen Access06 May 2025
Scientific Reports

Volume: 15, P: 1-11
Mild exercise activates renal dopamine system in mild hypertensives

T Sakai
M Ideishi
K Arakawa
Research06 Jul 1998
Journal of Human Hypertension

Volume: 12, P: 355-362
Science and Art at the Royal Academy

A. T. HOPWOOD
News17 May 1941
Nature

Volume: 147, P: 599-600
Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty

Timothy E. Yen
John C. Allen
Madan M. Kwatra
ResearchOpen Access05 Feb 2016
Scientific Reports

Volume: 6, P: 1-7

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