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Showing 1–50 of 78 results

Advanced filters: Author: T Pawson Clear advanced filters

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

Mark Henkemeyer
Derrick J. Rossi
Tony Pawson
Research26 Oct 1995
Nature

Volume: 377, P: 695-701
Hot gas and dark matter in a compact galaxy group

T. J. Ponman
D. Bertram
Research06 May 1993
Nature

Volume: 363, P: 51-54
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

M. Rozakis-Adcock
J. McGlade
T. Pawson
Research17 Dec 1992
Nature

Volume: 360, P: 689-692
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

M. Mohammadi
C. A. Dionne
J. Schlessinger
Research20 Aug 1992
Nature

Volume: 358, P: 681-684
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein

Nicholas T. Ktistakis
Maurine E. Linden
Michael G. Roth
Research26 Mar 1992
Nature

Volume: 356, P: 344-346
Structure of hisactophilin is similar to interleukin-1β and fibroblast growth factor

J. Habazettl
D. Gondol
T. A. Holak
Research29 Oct 1992
Nature

Volume: 359, P: 855-858
Long-term impact and biological recovery in a deep-sea mining track

Four decades after a test mining experiment that removed nodules, the biological impacts in many groups of organisms persist, although populations of several organisms have begun to re-establish despite persistent physical changes at the seafloor.

Daniel O. B. Jones
Maria Belen Arias
Adrian G. Glover
ResearchOpen Access26 Mar 2025
Nature

Volume: 642, P: 112-118
Isolation of the closed circular form of the transposable element Tc1 in Caenorhabditis elegans

A. M. Rose
T. P. Snutch
Research04 Oct 1984
Nature

Volume: 311, P: 485-486
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways

In the worm, netrin and the TGFβ-related molecule UNC-129 form opposing dorsoventral gradients. Motor axons are repelled by netrin and attracted to UNC-129, but no TGFβ receptors appear to be involved in the attraction. This study shows that UNC-129 enhances repulsive signaling from the netrin receptor complex UNC-5/UNC-40, via a direct interaction with UNC-5.

Lesley T MacNeil
W Rod Hardy
Joseph G Culotti
Research25 Jan 2009
Nature Neuroscience

Volume: 12, P: 150-155
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

Rina Plattner
Brenda J. Irvin
Ann Marie Pendergast
Research24 Mar 2003
Nature Cell Biology

Volume: 5, P: 309-319
Immunological activity of covalently linked T-cell epitopes

Franceso Ria
Bosco M. C. Chan
Malcolm L. Gefter
Research25 Jan 1990
Nature

Volume: 343, P: 381-383
Partial activation of CD8⁺ T cells by a self-derived peptide

Wuxiong Cao
Scott S. Tykodi
Thomas J. Braciale
Research16 Nov 1995
Nature

Volume: 378, P: 295-298
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition

Danette L. Daniels
Alexandra R. Cohen
Axel T. Brünger
Research01 Apr 1998
Nature Structural Biology

Volume: 5, P: 317-325
Structure and mobility of the PUT3 dimer

Kylie J. Walters
Kwaku T. Dayie
Gerhard Wagner
Research01 Sept 1997
Nature Structural Biology

Volume: 4, P: 744-750
Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells

M Yamaguchi
T Tanaka
S Irino
Research01 Apr 1997
Leukemia

Volume: 11, P: 497-503
SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor

S Marchetto
E Fournier
O Rosnet
Research09 Sept 1999
Leukemia

Volume: 13, P: 1374-1382
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Martin Turner
P. Joseph Mee
Victor L. J. Tybulewicz
Research16 Nov 1995
Nature

Volume: 378, P: 298-302
Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P₂ to the mSOS pleckstrin homology domain

Anne Bennett Jefferson
Anke Klippel
Lewis T Williams
Research26 May 1998
Oncogene

Volume: 16, P: 2303-2310
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

R.T. Nolte
M.J. Eck
S.C. Harrison
Research01 Apr 1996
Nature Structural Biology

Volume: 3, P: 364-374
Crystal structure of the annexin XII hexamer and implications for bilayer insertion

Hartmut Luecke
Bryna T. Chang
Harry T. Haigler
Research30 Nov 1995
Nature

Volume: 378, P: 512-515
Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 Å resolution

E. Y. Jones
K. Harlos
D. I. Stuart
Research09 Feb 1995
Nature

Volume: 373, P: 539-544
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca²⁺ flux but not mitogenesis

Kevin G. Peters
Jacky Marie
Lewis T. Williams
Research20 Aug 1992
Nature

Volume: 358, P: 678-681
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

Ronny Drapkin
Joyce T. Reardon
Danny Reinberg
Research21 Apr 1994
Nature

Volume: 368, P: 769-772
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a^18H mice

William L. Perry
Carolyn M. Hustad
Neal G. Copeland
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 143-146
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH₂-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret

Mario Chiariello
Roberta Visconti
Massimo Santoro
Research02 Jun 1998
Oncogene

Volume: 16, P: 2435-2445
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

Blood vessel development depends upon endothelial cell migration and adhesion, which are regulated by Rho-GTPases. Here the authors identify Rho-GTPase guanine nucleotide exchange factors that specifically control lateral filopodial contacts and are required for lumen formation during angiogenesis.

Sabu Abraham
Margherita Scarcia
Georgia Mavria
ResearchOpen Access01 Jul 2015
Nature Communications

Volume: 6, P: 1-14
Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton

Wei Li
Jianhua Fan
David T Woodley
Reviews17 Oct 2001
Oncogene

Volume: 20, P: 6403-6417
Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth

Zuzana Biesova
Claudia Piccoli
William T Wong
Research16 Jan 1997
Oncogene

Volume: 14, P: 233-241
Correction: Identification of the homologous beige and Chediak–Higashi syndrome genes

Maria D. F. S. Barbosa
Quan A. Nguyen
Stephen F. Kingsmore
Amendments and Corrections02 Jan 1997
Nature

Volume: 385, P: 97
Recombination in semiconductors

P. T. Landsberg
News & Views28 Sept 1978
Nature

Volume: 275, P: 270-271
The contribution of insects to global forest deadwood decomposition

Multi-year field experiments across six continents suggest that insects have an important contribution to decomposition and carbon release from forest deadwood.

Sebastian Seibold
Werner Rammer
Jörg Müller
Research01 Sept 2021
Nature

Volume: 597, P: 77-81
Synthetic Food

ARCHIBALD T. MCPHERSON
Correspondence09 Mar 1973
Nature

Volume: 242, P: 144-145
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller et al. provide a comprehensive resource depicting cellular substrates, localization and interacting partners of RhoGEF and RhoGAP proteins regulating the canonical Rho family of GTPases.

Paul M. Müller
Juliane Rademacher
Oliver Rocks
Research23 Mar 2020
Nature Cell Biology

Volume: 22, P: 498-511
Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells

T Ohtake
Y Fujimoto
Y Kohgo
ResearchOpen Access10 Sept 1999
British Journal of Cancer

Volume: 81, P: 393-403
Synthetic biology

Steven A. Benner
A. Michael Sismour
Reviews01 Jul 2005
Nature Reviews Genetics

Volume: 6, P: 533-543
Reading protein modifications with interaction domains

Proteins are controlled by post-translational modifications that can be recognized by specific protein-interaction domains. These domains read the state of the proteome and therefore couple post-translational modifications to cellular organization. But how domodification-dependent interactionssynergize to regulate cell behaviour?

Bruce T. Seet
Ivan Dikic
Tony Pawson
Reviews01 Jul 2006
Nature Reviews Molecular Cell Biology

Volume: 7, P: 473-483
Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts

Simon Plyte
M Bernardetta Majolini
Cosima T Baldari
Research16 Mar 2000
Oncogene

Volume: 19, P: 1529-1537
Absence of damaging effects of stem cell donation in unrelated donors assessed by FISH and gene variance screening

E. Nacheva
T. Ahyee
A. Madrigal
Research21 May 2020
Bone Marrow Transplantation

Volume: 55, P: 1290-1296
Oncogenic re-wiring of cellular signaling pathways

T Pawson
N Warner
Reviews26 Feb 2007
Oncogene

Volume: 26, P: 1268-1275
Navigating cancer network attractors for tumor-specific therapy

Pau Creixell
Erwin M Schoof
Rune Linding
Reviews10 Sept 2012
Nature Biotechnology

Volume: 30, P: 842-848
How Src exercises self-restraint

Two recent landmark structures of Src family kinases reveal how a sensitive conformational switch can be built with SH2 and SH3 domains.

Jack T. Nguyen
Wendell A. Lim
News & Views01 Apr 1997
Nature Structural Biology

Volume: 4, P: 256-260
Avian leukaemia viruses and haematopoietic cell differentiation

T Graf
H Beug
M J Hayman
Research01 Apr 1980
British Journal of Cancer

Volume: 41, P: 659-661
The ShcA SH2 domain engages a 14-3-3/PI3′K signaling complex and promotes breast cancer cell survival

J Ursini-Siegel
W R Hardy
W J Muller
Research30 Jan 2012
Oncogene

Volume: 31, P: 5038-5044
p63, a key regulator of Ago2, links to the microRNA-144 cluster

Benfan Wang
H. Helena Wu
Roger Leng
ResearchOpen Access22 Apr 2022
Cell Death & Disease

Volume: 13, P: 1-14
Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation

André AFL van Puijenbroek
David HJ van Weering
Jeroen den Hertog
Research13 Mar 1997
Oncogene

Volume: 14, P: 1147-1157
Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis

T Mizuno
S Kyoizumi
T Seyama
Research18 Sept 1997
Oncogene

Volume: 15, P: 1455-1460
Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia

H Kiyoi
T Naoe
R Ohno
Research01 Sept 1997
Leukemia

Volume: 11, P: 1447-1452
Elevated expression of the proto-oncogene c-kit in patients with mastocytosis

H Nagata
AS Worobec
DD Metcalfe
Research28 Apr 1998
Leukemia

Volume: 12, P: 175-181
Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues

X Chui
H Egami
M Ogawa
Research01 May 1996
British Journal of Cancer

Volume: 73, P: 1233-1236
Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

S Yokota
H Kiyoi
T Naoe
Research01 Oct 1997
Leukemia

Volume: 11, P: 1605-1609

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