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Showing 1–5 of 5 results
Advanced filters: Author: T. M. Zaved Waise Clear advanced filters

  • High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve glucose homeostasis by inhibiting hepatic glucose production.

    • Helen J. Dranse
    • T. M. Zaved Waise
    • Tony K. T. Lam
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.

    • T. M. Zaved Waise
    • Mozhgan Rasti
    • Tony K. T. Lam
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • The gastrointestinal tract participates in maintaining metabolic homeostasis in part through nutrient-sensing and subsequent gut-brain signalling. Here the authors review the role of small intestinal nutrient-sensing in regulation of energy intake and systemic glucose metabolism, and link high-fat diet, obesity and diabetes with perturbations in these pathways.

    • Frank A. Duca
    • T. M. Zaved Waise
    • Tony K. T. Lam
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Metabolic homeostasis is orchestrated partly in response to nutrient-dependent vagal afferent signals transmitted from the gut to the central nervous system. This Review highlights our understanding of the vagal afferent system and its role in regulation of appetite and glucose homeostasis.

    • T. M. Zaved Waise
    • Helen J. Dranse
    • Tony K. T. Lam
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 15, P: 625-636