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Showing 1–2 of 2 results
Advanced filters: Author: Tadas Kartanas Clear advanced filters

  • Manual sample deposition on a substrate can introduce artifacts in quantitative AFM measurements. Here the authors present a microfluidic spray device for reliable deposition of subpicoliter droplets which dry out in milliseconds after landing on the surface, thereby avoiding protein self-assembly.

    • Francesco Simone Ruggeri
    • Jerome Charmet
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Limbocker et al. show that trodusquemine, an aminosterol, reduces the cytotoxicity of protein misfolded oligomers by displacing them from cell membranes in the absence of any overt structural/ morphological changes in them. This mechanism appears to be general, as they test it for oligomers of αS, Aβ and the model protein HypF-N to human neuroblastoma cells.

    • Ryan Limbocker
    • Benedetta Mannini
    • Christopher M. Dobson
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-10