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Showing 1–5 of 5 results
Advanced filters: Author: Taifo Mahmud Clear advanced filters

  • The market demand for acarbose, a drug used for treatment of patients affected by type-2 diabetes, has increased. In this article, the authors report the acarbose complete biosynthetic pathway, clarifying previously unknown steps and identifying a pseudoglycosyltransferase enzyme, AcbS, a homologue of AcbI that catalyzes the formation of a non-glycosidic C-N bond.

    • Takeshi Tsunoda
    • Arash Samadi
    • Taifo Mahmud
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Characterization of multiple enzymes involves in biosynthesis of the aminocyclitol antibiotic pactamycin reveals a key step involving the glycosylation of an acyl carrier protein-bound intermediate by the promiscuous glycosyltransferase PtmJ.

    • Auday A. Eida
    • Mostafa E. Abugrain
    • Taifo Mahmud
    Research
    Nature Chemical Biology
    Volume: 15, P: 795-802

  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631