Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applied to attenuate a severe inflammation caused by another pathogen.
- Masataka Kawakita
- Taiki Oyama
- Kazuhiko Takahara
