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Showing 1–3 of 3 results
Advanced filters: Author: Taka-Aki Ichu Clear advanced filters

  • High-throughput screening and activity-based protein profiling find a selective and in vivo–active inhibitor of the membrane-associated serine hydrolase ABHD12 that alters lysophospholipid content and has immunostimulatory effects.

    • Daisuke Ogasawara
    • Taka-Aki Ichu
    • Benjamin F. Cravatt
    Research
    Nature Chemical Biology
    Volume: 14, P: 1099-1108

  • A deep chemical proteomic investigation of diverse aminophilic electrophiles has identified ligandable lysines across a wide range of human proteins. The proteins cover different functional and structural classes, and the aminophilic electrophiles include compounds that disrupt protein–protein and protein–RNA interactions. This dataset provides a proteome-wide atlas of lysine-reactive chemistry.

    • Mikail E. Abbasov
    • Madeline E. Kavanagh
    • Benjamin F. Cravatt
    Research
    Nature Chemistry
    Volume: 13, P: 1081-1092