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Showing 1–2 of 2 results
Advanced filters: Author: Takahiro Horimatsu Clear advanced filters

  • In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.

    • Nobuyuki Kakiuchi
    • Kenichi Yoshida
    • Seishi Ogawa
    Research
    Nature
    Volume: 577, P: 260-265

  • In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.

    • Akira Yokoyama
    • Nobuyuki Kakiuchi
    • Seishi Ogawa
    Research
    Nature
    Volume: 565, P: 312-317