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Showing 1–50 of 55 results

Advanced filters: Author: Takahiro Ochiya Clear advanced filters

Retraction Note: Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

Atsunori Kamiya
Yohsuke Hayama
Takahiro Ochiya
Amendments and Corrections29 Mar 2024
Nature Neuroscience

Volume: 27, P: 1020
Gene transfer and expression in progeny after intravenous DNA injection into pregnant mice

Makoto Tsukamoto
Takahiro Ochiya
Masaaki Terada
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 243-248
Distinct methylation levels of mature microRNAs in gastrointestinal cancers

In cancer it is assumed that microRNAs recognise and regulate their targets uniformly. Here, the authors show that in gastrointestinal cancers methylation of microRNAs may impact their stability, and that levels of microRNA methylation are distinct in pancreatic cancer patients compared to healthy controls with potential diagnostic implications.

Masamitsu Konno
Jun Koseki
Hideshi Ishii
ResearchOpen Access29 Aug 2019
Nature Communications

Volume: 10, P: 1-7
Correction: Corrigendum: RPN2 gene confers docetaxel resistance in breast cancer

Kimi Honma
Kyoko Iwao-Koizumi
Takahiro Ochiya
Amendments and Corrections01 Oct 2008
Nature Medicine

Volume: 14, P: 1128
Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice

Hanako Yamamoto
Takahiro Ochiya
Masaaki Terada
Research28 Jul 2000
Oncogene

Volume: 19, P: 3805-3810
New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet

Takahiro Ochiya
Yasushi Takahama
Masaaki Terada
Advertorial01 Jun 1999
Nature Medicine

Volume: 5, P: 707-710
Adenovirus-mediated transfer of HST-1/FGF-4 gene protects mice from lethal irradiation

Yasushi Takahama
Takahiro Ochiya
Masaaki Terada
Research21 Oct 1999
Oncogene

Volume: 18, P: 5943-5947
Statins attenuate PD-L1 sorting to small extracellular vesicles dependent on ubiquitin-like 3 modification

Hiroshi Ageta
Yoshihisa Shimada
Kunihiro Tsuchida
ResearchOpen Access15 Dec 2025
Scientific Reports

Volume: 15, P: 1-12
RETRACTED ARTICLE: Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

Genetic techniques to manipulate autonomic nerves in a tumor- and fiber-type-specific manner in rodent models of breast cancer reveal that sympathetic nerve denervation or parasympathetic nerve stimulation suppresses breast cancer growth and progression.

Atsunori Kamiya
Yohsuke Hayama
Takahiro Ochiya
Research08 Jul 2019
Nature Neuroscience

Volume: 22, P: 1289-1305
A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes

Sarcomas are rare malignant tumours of bone and soft tissue whose diagnosis remain difficult. Here, the authors analyse serum samples from over 1000 patients and using separate discovery, training and validation cohorts, identify and validate a 7-microRNA index that distinguishes malignant sarcomas from benign disease.

Naofumi Asano
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-10
AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells

Runa Izutsu
Mitsuhiko Osaki
Futoshi Okada
ResearchOpen Access17 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data

Yuya Asanomi
Daichi Shigemizu
Shumpei Niida
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Stress-induced brain extracellular vesicles ameliorate anxiety behavior

Yusuke Mizohata
Yusuke Yoshioka
Yuji Morimoto
ResearchOpen Access18 Nov 2025
Translational Psychiatry

Volume: 15, P: 1-12
Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

Combining mouse hepatocyte progenitors and cholangiocytes ex vivo, the authors form an organoid that can drain bile ex vivo and transport metabolites, as in the liver.

Naoki Tanimizu
Norihisa Ichinohe
Toshihiro Mitaka
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo

Bone remodeling involves a switch between bone formation and resorption, but the mechanisms is unclear. Here, the authors show that intercellular communication via extracellular vesicles secreted by mature osteoblasts is a key factor for the switching, via a microRNA-mediated mechanism.

Maki Uenaka
Erika Yamashita
Masaru Ishii
ResearchOpen Access24 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Integrated extracellular microRNA profiling for ovarian cancer screening

Screening methods for early detection of ovarian cancer is technically difficult. Here, the authors investigated circulating microRNA in human blood serum and developed a model using 10 microRNAs to discern between ovarian cancer and being ovarian tumors, solid tumors, and non-cancer patients.

Akira Yokoi
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access17 Oct 2018
Nature Communications

Volume: 9, P: 1-10
A robust screening method for dietary agents that activate tumour-suppressor microRNAs

Keitaro Hagiwara
Luc Gailhouste
Takahiro Ochiya
ResearchOpen Access01 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Identification of the novel 3′ UTR sequences of human IL-21 mRNA as potential targets of miRNAs

Yutaka Enomoto
Rie Takagi
Atsushi Miyajima
ResearchOpen Access10 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
HST-1/FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation

Hideo Sasaki
Kotaro Hirai
Takahiro Ochiya
Research29 Apr 2004
Oncogene

Volume: 23, P: 3681-3688
Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

The potential of extracellular vesicles (EVs) as cancer biomarkers is substantial. Here, Yoshioka et al. describe a sensitive technique to analyse EVs directly from blood samples of patients with colorectal cancer, highlighting a liquid biopsy technique with cancer-detection possibilities.

Yusuke Yoshioka
Nobuyoshi Kosaka
Takahiro Ochiya
ResearchOpen Access07 Apr 2014
Nature Communications

Volume: 5, P: 1-8
Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

Ovarian cancer is particularly deadly because it is difficult to detect at the pre-metastatic stage; extracellular vesicles (EVs) on the other hand are involved in the pre-metastatic niche preparation. Here the authors show that EVs mediate ovarian cancer metastasis in the peritoneal area by targeting the mesothelium.

Akira Yokoi
Yusuke Yoshioka
Takahiro Ochiya
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-15
Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

A key event during metastasis to the brain is the migration of cancer cells through the blood–brain barrier (BBB). Here the authors show that cancer-cell-derived extracellular vesicles promote metastasis by promoting BBB breaching.

Naoomi Tominaga
Nobuyoshi Kosaka
Takahiro Ochiya
ResearchOpen Access01 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment

IL-33 is a pro-inflammatory cytokine with a role in colorectal cancer. Here, the authors show that circulating tumour-derived sST2, an IL-33 decoy receptor, delayed the growth and progression of colorectal cancer cells by inhibiting Th1/Th2 polarization, macrophage infiltration and angiogenesis.

Miho Akimoto
Riruke Maruyama
Keizo Takenaga
ResearchOpen Access24 Nov 2016
Nature Communications

Volume: 7, P: 1-15
Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1

MicroRNAs have a role in the acquisition of stem cell-like properties of cancer cells. Here the authors show that microRNA-27b mediates generation of a side-population of breast cancer stem cells, in part by regulating the protein ENPP1, which has been previously linked to the development of diabetes.

Ryou-u Takahashi
Hiroaki Miyazaki
Takahiro Ochiya
ResearchOpen Access12 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications

Nobuyoshi Kosaka
Akiko Kogure
Takahiro Ochiya
ReviewsOpen Access15 Mar 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-9
Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids

Aya Yoshimura
Masaki Kawamata
Yoshitaka Tamai
ResearchOpen Access19 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
UBL3 modification influences protein sorting to small extracellular vesicles

Exosomes mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs but the mechanisms of protein sorting to exosomes are poorly understood. Here, the authors uncover that ubiquitin-like 3 (UBL3) regulates protein sorting to exosomes by acting as a posttranslational modification.

Hiroshi Ageta
Natsumi Ageta-Ishihara
Kunihiro Tsuchida
ResearchOpen Access26 Sept 2018
Nature Communications

Volume: 9, P: 1-12
Extracellular vesicle-associated microRNA signatures related to lymphovascular invasion in early-stage lung adenocarcinoma

Yoshihisa Shimada
Yusuke Yoshioka
Norihiko Ikeda
ResearchOpen Access24 Mar 2023
Scientific Reports

Volume: 13, P: 1-9
Molecular cloning and functional analysis of cDNA encoding a rat leukemia inhibitory factor: towards generation of pluripotent rat embryonic stem cells

Yasushi Takahama
Takahiro Ochiya
Masaaki Terada
Research17 Jun 1998
Oncogene

Volume: 16, P: 3189-3196
RPN2 gene confers docetaxel resistance in breast cancer

Resistance to drugs is a clinical problem. Downregulating the gene RPN2, which encodes part of an N-oligosaccharyl transferase complex, sensitized breast cancer cells to the cancer drug docetaxel in vivo and in vitro. RPN2 might be a therapeutic target against drug resistance in cancer.

Kimi Honma
Kyoko Iwao-Koizumi
Takahiro Ochiya
Research17 Aug 2008
Nature Medicine

Volume: 14, P: 939-948
A novel platform to enable inhaled naked RNAi medicine for lung cancer

Yu Fujita
Fumitaka Takeshita
Takahiro Ochiya
ResearchOpen Access25 Nov 2013
Scientific Reports

Volume: 3, P: 1-9
Usefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery

Yu Akazawa
Shoichi Mizuno
Tetsuya Nakatsura
ResearchOpen Access11 Apr 2019
Scientific Reports

Volume: 9, P: 1-12
Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling

Human bronchial epithelial cell-derived EVs exhibit immunomodulatory properties through miRNAs & ANXA1, which can suppress NF-κB signaling. The study holds promise as a novel approach for mitigating lung injury and inflammation in acute lung injury.

Yu Fujita
Tsukasa Kadota
Jun Araya
ResearchOpen Access06 May 2024
Communications Biology

Volume: 7, P: 1-11
HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity

Hanako Yamamoto
Takahiro Ochiya
Masaaki Terada
Research12 Feb 2002
Oncogene

Volume: 21, P: 899-908
Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis

Suguru Takeuchi
Atsunori Tsuchiya
Shuji Terai
ResearchOpen Access30 Mar 2021
npj Regenerative Medicine

Volume: 6, P: 1-14
Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma

Koji Uotani
Tomohiro Fujiwara
Toshifumi Ozaki
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Plasma extracellular vesicle microRNAs reflecting the therapeutic effect of the CBP/β-catenin inhibitor PRI-724 in patients with liver cirrhosis

Mayu Yoshida
Juntaro Matsuzaki
Kiminori Kimura
ResearchOpen Access15 Mar 2024
Scientific Reports

Volume: 14, P: 1-15
miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells

Chisaho Torii
Nako Maishi
Kyoko Hida
ResearchOpen Access05 Jul 2021
Scientific Reports

Volume: 11, P: 1-16
Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells

Luc Gailhouste
Masayuki Sudoh
Yutaka Furutani
ResearchOpen Access02 Jun 2021
Cell Death Discovery

Volume: 7, P: 1-11
Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA

Hiroshi Yukawa
Shuji Yamazaki
Yoshinobu Baba
ResearchOpen Access21 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts

Yutaka Naito
Yusuke Yamamoto
Takahiro Ochiya
ResearchOpen Access30 May 2019
Oncogene

Volume: 38, P: 5566-5579
MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells

Luc Gailhouste
Lee Chuen Liew
Takahiro Ochiya
ResearchOpen Access18 Jul 2019
Cell Death & Disease

Volume: 10, P: 1-16
Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells

Hiroshi Yukawa
Kaoru Suzuki
Yoshinobu Baba
ResearchOpen Access30 Apr 2018
Scientific Reports

Volume: 8, P: 1-12
Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data

Daichi Shigemizu et al. developed a risk prediction model using potential miRNA biomarkers of different dementias identified by a supervised principal component analysis logistic regression method. Their models achieved high accuracy when tested on a validation cohort and demonstrate the potential application of miRNA-based risk prediction models.

Daichi Shigemizu
Shintaro Akiyama
Shumpei Niida
ResearchOpen Access25 Feb 2019
Communications Biology

Volume: 2, P: 1-8
Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells

Luc Gailhouste
Lee Chuen Liew
Takahiro Ochiya
ResearchOpen Access27 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-12
A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

Asakura, Kadota et al. demonstrate the diagnostic potential of serum microRNAs for resectable lung cancer. Their diagnostic model based on the combined expression levels of two miRNAs predicts resectable lung cancer with 99% sensitivity, regardless of histological types and pathological stages of cancer, suggesting its promising, diagnostic utility.

Keisuke Asakura
Tsukasa Kadota
Takahiro Ochiya
ResearchOpen Access19 Mar 2020
Communications Biology

Volume: 3, P: 1-9
The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas

Makoto Miyazaki
Ryo Otomo
Masato Enari
ResearchOpen Access10 May 2018
Cell Death Discovery

Volume: 4, P: 1-17
Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β

Ryou-u Takahashi
Fumitaka Takeshita
Takahiro Ochiya
ResearchOpen Access20 Aug 2013
Scientific Reports

Volume: 3, P: 1-13
Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner

Yuri N. Urata
Fumitaka Takeshita
Masato Takimoto
ResearchOpen Access08 Sept 2015
Scientific Reports

Volume: 5, P: 1-12
Two distinct knockout approaches highlight a critical role for p53 in rat development

Masaki Kawamata
Takahiro Ochiya
ResearchOpen Access10 Dec 2012
Scientific Reports

Volume: 2, P: 1-10

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