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Showing 1–5 of 5 results

Advanced filters: Author: Takahiro Otabe Clear advanced filters

A split CRISPR–Cpf1 platform for inducible genome editing and gene activation

Split Cpf1 pairs are identified to enable chemical- and light-induced genome editing via dimerization. Another pair of split Cpf1 can be used to activate gene expression with high efficiency in cells and in mice.

Yuta Nihongaki
Takahiro Otabe
Moritoshi Sato
Research12 Aug 2019
Nature Chemical Biology

Volume: 15, P: 882-888
A red light–responsive photoswitch for deep tissue optogenetics

A photoswitch based on a bacterial phytochrome enables optogenetic manipulations using red light.

Yuto Kuwasaki
Kazushi Suzuki
Moritoshi Sato
Research13 Jun 2022
Nature Biotechnology

Volume: 40, P: 1672-1679
A chemically inducible, leakless Cre recombinase by split-protein-based efficient and enhanced degradation (SPEED)

A combination of self-assembling split-Cre with a destabilizing domain system is found to be an effective way to improve the degradation efficiency of destabilized Cre in the absence of Trimethoprim (Tmp) while maintaining efficient TMP-inducible DNA recombination.

Dewen Cai
Fuun Kawano
Moritoshi Sato
ResearchOpen Access14 Dec 2025
Communications Biology

Volume: 9, P: 1-11
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

Naphthyridine-azaquinolone specifically binds slipped-CAG DNA intermediates, induces contractions of expanded repeats and reduces mutant HTT protein aggregates in cell and animal models of Huntington’s disease.

Masayuki Nakamori
Gagan B. Panigrahi
Christopher E. Pearson
Research14 Feb 2020
Nature Genetics

Volume: 52, P: 146-159
CRISPR–Cas9-based photoactivatable transcription systems to induce neuronal differentiation

Blue-light-inducible CRISPR-based transcriptional activation systems achieve high enough endogenous gene expression to trigger the differentiation of iPSCs.

Yuta Nihongaki
Yuichi Furuhata
Moritoshi Sato
Research11 Sept 2017
Nature Methods

Volume: 14, P: 963-966