Nature Search

Adrenomedullin Inhibits Angiotensin II-Induced Oxidative Stress and Gene Expression in Rat Endothelial Cells

Takanobu Yoshimoto
Naoki Gochou
Yukio Hirata
Research01 Feb 2005
Hypertension Research

Volume: 28, P: 165-172
Polysilane–Silica Hybrid Nanoparticles

Takanobu Sanji
Yuriko Nakatsuka
Hideki Sakurai
Research14 Jan 2005
Polymer Journal

Volume: 37, P: 1-6
Odour concentration-dependent olfactory preference change in C. elegans

Some animals find the same odorant attractive at low concentrations and repulsive at high concentrations, but how this discrimination occurs is unclear. UsingCaenorhabditis elegans as a model system, Yoshida et al. show that different sets of sensory neurons respond to low and high concentrations of odours.

Kazushi Yoshida
Takaaki Hirotsu
Takeshi Ishihara
Research13 Mar 2012
Nature Communications

Volume: 3, P: 1-11
132 CLINICO-BIOCHEMICAL AND MOLECULAR STUDIES OF PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY

Takeshi Sakiyama
Munenori Iwase
Teruo Kitagawa
Research01 Jul 1988
Pediatric Research

Volume: 24, P: 133
Author Correction: Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Christopher J. Vavricka
Takanobu Yoshida
Akihiko Kondo
Amendments and CorrectionsOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1
Machine learning discovery of missing links that mediate alternative branches to plant alkaloids

Producing plant secondary metabolites by microbes is limited by the known enzymatic reactions. Here, the authors apply machine learning to predict missing link enzymes of benzylisoquinoline alkaloid (BIA) biosynthesis in Papaver somniferum, and validate the specialized activities through heterologous production.

Christopher J. Vavricka
Shunsuke Takahashi
Tomohisa Hasunuma
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Bioproduction of tetrahydropapaveroline (THP) is limited by the specificity of monoamine oxidase (MAO). Here, the authors identify an insect 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) that can bypass MAO for direct aldehyde production and demonstrate bifunctional switching of DHPAAS for efficient THP production.

Christopher J. Vavricka
Takanobu Yoshida
Akihiko Kondo
ResearchOpen Access01 May 2019
Nature Communications

Volume: 10, P: 1-11
Novel neuroblastoma amplified sequence (NBAS) mutations in a Japanese boy with fever-triggered recurrent acute liver failure

Sahoko Ono
Junko Matsuda
Kazunobu Ouchi
ResearchOpen Access07 Jan 2019
Human Genome Variation

Volume: 6, P: 1-9
Diverse pathological lesions of primary aldosteronism and their clinical significance

Koshiro Nishimoto
Hironobu Umakoshi
Chiba Yoshiro
ResearchOpen Access12 Jan 2021
Hypertension Research

Volume: 44, P: 498-507
Tenascin C protects aorta from acute dissection in mice

Taizo Kimura
Kozoh Shiraishi
Hiroki Aoki
ResearchOpen Access11 Feb 2014
Scientific Reports

Volume: 4, P: 1-10
Clinical manifestations in two patients with pyruvate dehydrogenase deficiency and long-term survival

Takanobu Yoshida
Jun Kido
Kimitoshi Nakamura
ResearchOpen Access01 Jun 2017
Human Genome Variation

Volume: 4, P: 1-4
Replication of a genome-wide association study of panic disorder in a Japanese population

Takeshi Otowa
Hisashi Tanii
Tsukasa Sasaki
Research04 Dec 2009
Journal of Human Genetics

Volume: 55, P: 91-96
Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer

Mimura et al. report findings from a single arm, phase I/II study of combined radiation and anti-PD-1 therapy in patients with advanced or recurrent gastric cancer. Combination therapy achieves a disease control rate of 22.5% for non-irradiated lesions via an abscopal effect, or 40% for irradiated lesions, and a median survival time of 230 days.

Kosaku Mimura
Takashi Ogata
Koji Kono
ResearchOpen Access15 Aug 2023
Communications Medicine

Volume: 3, P: 1-7
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination

Yusuke Miyashita
Takanobu Yoshida
Hiroyuki Oshiumi
ResearchOpen Access08 Feb 2022
npj Vaccines

Volume: 7, P: 1-11
A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture

Han-Hsiu Hsu
Michihiro Araki
Akihiko Kondo
ResearchOpen Access02 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

Kawaguchi et al. show that mice deficient in lipocalin-type prostaglandin (PG) D synthase (L-PGDS) exhibit impaired light-induced phase advance, but normal phase delay and nonvisual light responses. This study suggests the role of L-PGDS for the light-induced phase advance possibly via a chemoattractant receptor DP2/CRTH2.

Chihiro Kawaguchi
Norihito Shintani
Hitoshi Hashimoto
ResearchOpen Access08 Oct 2020
Communications Biology

Volume: 3, P: 1-13

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Adrenomedullin Inhibits Angiotensin II-Induced Oxidative Stress and Gene Expression in Rat Endothelial Cells

Polysilane–Silica Hybrid Nanoparticles

Odour concentration-dependent olfactory preference change in C. elegans

132 CLINICO-BIOCHEMICAL AND MOLECULAR STUDIES OF PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY

Author Correction: Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Machine learning discovery of missing links that mediate alternative branches to plant alkaloids

Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Novel neuroblastoma amplified sequence (NBAS) mutations in a Japanese boy with fever-triggered recurrent acute liver failure

Diverse pathological lesions of primary aldosteronism and their clinical significance

Tenascin C protects aorta from acute dissection in mice

Clinical manifestations in two patients with pyruvate dehydrogenase deficiency and long-term survival

Replication of a genome-wide association study of panic disorder in a Japanese population

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer

Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination

A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

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