Nature Search

Tumour Production in Glandular Stomach of Rat by N-Methyl-N′-Nitro-N-Nitrosoguanidine

TAKASHI SUGIMURA
SHINJI FUJIMURA
Research02 Dec 1967
Nature

Volume: 216, P: 943-944
Occurrence of PER-1 Producing Clinical Isolates of Pseudomonas aeruginosa in Japan and their Susceptibility to Doripenem

Yoshinori Yamano
Toru Nishikawa
Hideaki Miwa
Research01 Dec 2006
The Journal of Antibiotics

Volume: 59, P: 791-796
Structure of a replication-terminator protein complexed with DNA

Katsuhiko Kamada
Takashi Horiuchi
Kosuke Morikawa
Research17 Oct 1996
Nature

Volume: 383, P: 598-603
Examination of the predicted prevalence of Gitelman syndrome by ethnicity based on genome databases

Atsushi Kondo
China Nagano
Kandai Nozu
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-7
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Correction: Corrigendum: TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

Ken-ichi Takayama
Aya Misawa
Satoshi Inoue
Amendments and Corrections14 Dec 2015
Nature Communications

Volume: 6, P: 1
Unique pioneer microbial communities exposed to volcanic sulfur dioxide

Reiko Fujimura
Seok-Won Kim
Hiroyuki Ohta
ResearchOpen Access21 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy

Patients with myotonic dystrophy (MD) suffer from severe cardiac issues of unknown aetiology. Freyermuth et al. show that fatal changes in cardiac electrophysiological properties in humans and mice with MD may arise from misregulation of the alternative splicing of the cardiac Na⁺ channel SCN5Atranscript, resulting in expression of its fetal form.

Fernande Freyermuth
Frédérique Rau
Nicolas Charlet-Berguerand
ResearchOpen Access11 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Negative fallout from public sentiment in Japan

Kazuo N. Watanabe
Tatsuhito Fujimura
Tomoyuki Yamaya
Correspondence01 Aug 2004
Nature Biotechnology

Volume: 22, P: 943
Stage-specific GATA3 induction promotes ILC2 development after lineage commitment

The transcription factor GATA3 is enhanced in innate lymphoid type 2 cells (ILC2). Here the authors characterize the super enhancer regions of GATA3 and show that these enhancers are required to drive GATA3 expression and stage specific ILC2 development.

Hiroki Furuya
Yosuke Toda
Hiroshi Nakajima
ResearchOpen Access05 Jul 2024
Nature Communications

Volume: 15, P: 1-16
Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis

IPF is a progressive disease with few inflammatory pathology. Here, using alveolar organoid technology, the authors identified autocrine TGF-β-positive feedback in AT2-lineage cells as a core mechanism of inflammation-independent lung fibrogenesis.

Yasunori Enomoto
Hiroaki Katsura
Mitsuru Morimoto
ResearchOpen Access31 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

Takashi Adachi-Yamada
Konomi Fujimura-Kamada
Kunihiro Matsumoto
Research08 Jul 1999
Nature

Volume: 400, P: 166-169
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Dysregulation of p62 has been implicated in tumorigenesis. Here, the authors show that p62 promotes hepatocellular carcinoma by reprogramming glucose and glutamine metabolism through Nrf2 and present a novel compound that can inhibit p62 action thus sensitizing cancer cells to chemotherapy.

Tetsuya Saito
Yoshinobu Ichimura
Masaaki Komatsu
ResearchOpen Access27 Jun 2016
Nature Communications

Volume: 7, P: 1-16
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions

The regulation of meiotic prophase progression varies between males and females. This study reveals the involvement of an atypical heat shock transcription factor HSF5 in gene expression during male meiotic prophase and highlights the involved gene regulatory mechanism.

Saori Yoshimura
Ryuki Shimada
Kei-ichiro Ishiguro
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-22
Prenatal diagnosis of peroxisomal d-3-hydroxyacyl-CoA dehydratase / d-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency

Y. Suzuki
Zhongyi Zhang
Naomi Kondo
Research01 May 1999
Journal of Human Genetics

Volume: 44, P: 143-147
A Neonate With Löffler Syndrome

Juri Fujimura
Yukari Murakami
Yositaka Fukunaga
Research14 Aug 2001
Journal of Perinatology

Volume: 21, P: 207-208
Methylmercury induces the expression of TNF-α selectively in the brain of mice

Miyuki Iwai-Shimada
Tsutomu Takahashi
Gi-Wook Hwang
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-8
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

The authors add to our knowledge of the transcriptional regulation of the meiotic program in mice spermatocytes, showing ZFP541 regulates meiotic prophase and transition to the division phase by being the target for upstream factors MEIOSIN/STRA8.

Yuki Horisawa-Takada
Chisato Kodera
Kei-Ichiro Ishiguro
ResearchOpen Access01 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer

Transcription factors (TFs) often form distinct networks to regulate transcriptional program during cancer progression. Here the authors show that OCT4 is a common transcriptional factor in two types of advanced PC and as such, OCT4 accelerates a TF complex formation with the FOXA1/AR in castration-resistant PC and NRF1 in neuroendocrine PC.

Ken-ichi Takayama
Takeo Kosaka
Satoshi Inoue
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-16
TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

The epigenetic mark 5-hmC alters gene expression and is known to be regulated by TET proteins. Here, the authors show that 5-hmC and TET2 are reduced in prostate cancer via androgen receptor-dependent miRNA expression and are inversely correlated with prognosis.

Ken-ichi Takayama
Aya Misawa
Satoshi Inoue
Research25 Sept 2015
Nature Communications

Volume: 6, P: 1-16
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Both higher fitness level and higher current physical activity level may be required for intramyocellular lipid accumulation in non-athlete men

Nozomu Yamasaki
Yoshifumi Tamura
Hirotaka Watada
ResearchOpen Access05 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Intestinal microfold (M) cells actively capture luminal antigens and move them by transcytosis to initiate immune responses. Ohno and colleagues show that the Ets transcription factor Spi-B is necessary for M-cell differentiation.

Takashi Kanaya
Koji Hase
Hiroshi Ohno
Research17 Jun 2012
Nature Immunology

Volume: 13, P: 729-736
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

Lysine-specific demethylase 1 (LSD1) removes methyl groups from mono-methylated and dimethylated lysine 4 of histone H3 and represses transcription. In this study, a role for LSD1 in the regulation of genes involved in energy expenditure in adipocytes is reportedin vitroand in mice fed on a high-fat diet.

Shinjiro Hino
Akihisa Sakamoto
Mitsuyoshi Nakao
ResearchOpen Access27 Mar 2012
Nature Communications

Volume: 3, P: 1-12
Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins

Nourin Jahan
Hiroyuki Ohsaki
Akira Nishiyama
ResearchOpen Access29 Mar 2023
Scientific Reports

Volume: 13, P: 1-13
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia

Takashi Toyama
Takayuki Hoshi
Gi-Wook Hwang
ResearchOpen Access10 May 2021
Scientific Reports

Volume: 11, P: 1-13
Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Takashi Funayama
Yoshifumi Tamura
Hirotaka Watada
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Identification of target genes for EWS/ATF-1 chimeric transcription factor

Miki Jishage
Takashi Fujino
Takuro Nakamura
Research14 Jan 2003
Oncogene

Volume: 22, P: 41-49
An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population

Taku Miyagawa
Hiromi Toyoda
Katsushi Tokunaga
ResearchOpen Access17 Sept 2015
Human Genome Variation

Volume: 2, P: 1-4
Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G⁺ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice

Jun Takai
Hiroshi Ohtsu
Takashi Moriguchi
ResearchOpen Access30 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
FGFR blockade inhibits targeted therapy-tolerant persister in basal FGFR1- and FGF2-high cancers with driver oncogenes

Koh Furugaki
Takaaki Fujimura
Shigeki Yoshiura
ResearchOpen Access25 Oct 2023
npj Precision Oncology

Volume: 7, P: 1-15
Angle change of the A-domain in a single SERCA1a molecule detected by defocused orientation imaging

Takanobu A. Katoh
Takashi Daiho
Hiroshi Suzuki
ResearchOpen Access01 Jul 2021
Scientific Reports

Volume: 11, P: 1-12
A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia

Taku Miyagawa
Seik-Soon Khor
Katsushi Tokunaga
Research28 Sept 2018
Journal of Human Genetics

Volume: 63, P: 1259-1267
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr^−/− mouse model

Motoko Kuba
Takashi Matsuzaka
Hitoshi Shimano
ResearchOpen Access01 Dec 2015
Scientific Reports

Volume: 5, P: 1-14
Strain Dependent Electronic Structure and Band Offset Tuning at Heterointerfaces of ASnO₃ (A=Ca, Sr, and Ba) and SrTiO₃

John D. Baniecki
Takashi Yamazaki
Yoshihiko Imanaka
ResearchOpen Access14 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Low-cesium rice: mutation in OsSOS2 reduces radiocesium in rice grains

Satoru Ishikawa
Shimpei Hayashi
Hiroki Takagi
ResearchOpen Access25 May 2017
Scientific Reports

Volume: 7, P: 1-15
Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis model

Satoshi Sunahara
Eizo Watanabe
Shigeto Oda
ResearchOpen Access18 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

Ken-ichi Takayama
Takashi Suzuki
Satoshi Inoue
Research30 Jan 2018
Oncogene

Volume: 37, P: 2165-2180
Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection

Shinya Kasamatsu
Akira Hachiya
Yoshinori Takema
ResearchOpen Access22 Nov 2011
Scientific Reports

Volume: 1, P: 1-10
Novel TPR-containing subunit of TOM complex functions as cytosolic receptor for Entamoeba mitosomal transport

Takashi Makiuchi
Fumika Mi-ichi
Tomoyoshi Nozaki
ResearchOpen Access24 Jan 2013
Scientific Reports

Volume: 3, P: 1-7
Correlates of insulin clearance in apparently healthy non-obese Japanese men

Hideyoshi Kaga
Yoshifumi Tamura
Hirotaka Watada
ResearchOpen Access03 May 2017
Scientific Reports

Volume: 7, P: 1-8
Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis

Sumitaka Yamanaka
Makoto Sunamura
Akira Horii
Research09 Aug 2004
Laboratory Investigation

Volume: 84, P: 1339-1351

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