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Showing 1–4 of 4 results

Advanced filters: Author: Takehiro Kamo Clear advanced filters

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

Histone acetylation activates gene transcription but its direct read/write mechanism is unknown. Here the authors show by cryo-electron microscopy that p300/CBP reads acetylation at histone H4 and writes it to other histones in the nucleosome.

Masaki Kikuchi
Satoshi Morita
Takashi Umehara
ResearchOpen Access17 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Conformational alteration of DOCK5•ELMO1 signalosome on lipid membrane

Membrane-flattened DOCK5–ELMO1–RhoG–Rac1 complexes reveal that conformational changes from hinge rotations and ELMO1 PH domain–lipid interactions cooperatively regulate DOCK5 GEF activity and downstream signalling.

Takehiro Shinoda
Kazushige Katsura
Mikako Shirouzu
ResearchOpen Access13 Nov 2025
Communications Biology

Volume: 8, P: 1-10
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

Chizuru Yabumoto
Hiroshi Akazawa
Issei Komuro
ResearchOpen Access25 Sept 2015
Scientific Reports

Volume: 5, P: 1-15
Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD⁺ protects the heart against pressure overload

Masamichi Yano
Hiroshi Akazawa
Issei Komuro
ResearchOpen Access02 Nov 2015
Scientific Reports

Volume: 5, P: 1-14