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Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas

Oncoprotein SS18-SSX is a hallmark of synovial sarcoma. Here the authors report phase separation of SS18-SSX and the binding of SS18-SSX to chromatin remodeling complex are important for the transformation activity of the oncoprotein SS18-SSX.

Yanli Cheng
Zhongtian Shen
Jiafu Long
ResearchOpen Access18 May 2022
Nature Communications

Volume: 13, P: 1-13

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Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas

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