Fujinami et al. show that an antimicrobial peptide Nukacin ISK-1 exists in an equilibrium between two states, only one of which can bind to the ISK-1’s target lipid-II, an important bacterial cell wall precursor. This study provides unexpected insights into the action modes of antibiotics.
- Daisuke Fujinami
- Abdullah-Al -Mahin
- Kenji Sonomoto
