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Showing 1–4 of 4 results

Advanced filters: Author: Takuya Uehata Clear advanced filters

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

The interferon-inducible RNA-binding protein N4BP1 binds to and degrades HIV-1 mRNAs, thus inhibiting viral degradation and promoting viral latency. However, metacaspase-mediated degradation of N4BP1 following activation of CD4⁺ T cells facilitates HIV-1 latency reversal.

Daichi Yamasoba
Kei Sato
Osamu Takeuchi
Research27 May 2019
Nature Microbiology

Volume: 4, P: 1532-1544
NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

A new technique called NET-CAGE identifies 5′ ends of nascent RNAs with high sensitivity, including enhancer-derived RNAs. This approach shows that enhancer–promoter pairs are generally activated simultaneously.

Shigeki Hirabayashi
Shruti Bhagat
Yasuhiro Murakawa
Research02 Sept 2019
Nature Genetics

Volume: 51, P: 1369-1379
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

The stability of interleukin 6 transcripts is negatively regulated by the RNAse regnase-1. Akira and colleagues show that regnase-1 is targeted for degradation by phosphorylation mediated by the kinase IKK, which allows more interleukin 6 production.

Hidenori Iwasaki
Osamu Takeuchi
Shizuo Akira
Research30 Oct 2011
Nature Immunology

Volume: 12, P: 1167-1175
Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia

Yoshinari Nakatsuka
Alexis Vandenbon
Osamu Takeuchi
Research25 Apr 2018
Mucosal Immunology

Volume: 11, P: 1203-1218