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Showing 1–2 of 2 results
Advanced filters: Author: Tala Shekarian Clear advanced filters

  • Although it has shown high efficacy in many tumor types, interleukin-12 (IL-12) treatment provokes severe systemic toxicity. Here, the authors discover that use of an IL-12Fc fusion cytokine with abolished binding to the neonatal Fc receptor presents efficacy in local glioblastoma therapy while preventing toxicity.

    • Michal Beffinger
    • Linda Schellhammer
    • Johannes vom Berg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • EGFRvIII-targeted CAR T cells have been proposed as a therapeutic option for patients with glioblastoma (GBM), however, clinical responses remain suboptimal. Here the authors engineer anti-EGFRvIII CAR T cells to secrete an optimized SIRPγ-derived CD47 blocker, showing that combining CAR T cell effector functions with enhanced macrophage-mediated tumor cell phagocytosis improves anti-tumor efficacy in preclinical models.

    • Tomás A. Martins
    • Deniz Kaymak
    • Gregor Hutter
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25