The segmentation of the Drosophila melanogaster embryo is a well-known paradigm for pattern formation in development. However, the quantitative description of the transcriptional control mechanisms underlying this process is still missing. A new approach to the problem of predicting the pattern of gene expression based on cis-regulatory sequence is described. This new algorithm modelling protein–DNA interactions is likely to prove useful for many other protein–DNA interaction systems.
- Eran Segal
- Tali Raveh-Sadka
- Ulrike Gaul
