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Association of CD4-positive cell infiltration with response to vedolizumab in patients with ulcerative colitis

Haruka Miyazaki
Namiko Hoshi
Yuzo Kodama
ResearchOpen Access20 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity

Somatic mutations in ASXL1 lead to clonal hematopoiesis, and Sato et al. elucidate the molecular mechanisms by which mutated ASXL1 in hematopoietic cells drives atherosclerosis in mice.

Naru Sato
Susumu Goyama
Toshio Kitamura
Research09 Dec 2024
Nature Cardiovascular Research

Volume: 3, P: 1568-1583
Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia

Natural Killer (NK) cells play a role in suppressing the development of certain subtypes of acute myeloid leukemia as shown by employing Rag2^−/− mice as model system, which lack functional lymphocytes but have hyperactive NK cells.

Emi Sugimoto
Jingmei Li
Susumu Goyama
ResearchOpen Access21 Dec 2023
Communications Biology

Volume: 6, P: 1-12