Nature Search

Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas

Justus B. Cohen
Tamar Unger
David Givol
Research22 Dec 1983
Nature

Volume: 306, P: 797-799
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

Tamar Unger
Ronit Vogt Sionov
Ygal Haupt
Research25 May 1999
Oncogene

Volume: 18, P: 3205-3212
Correction: Corrigendum: Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

Prashant D. Sonawane
Jacob Pollier
Asaph Aharoni
Amendments and Corrections12 Jun 2017
Nature Plants

Volume: 3, P: 1
Enzymes as viscoelastic catalytic machines

Enzymes are viscoelastic, deformable machines. Mutating high-strain regions in these machines affect their catalytic function.

Eyal Weinreb
John M. McBride
Tsvi Tlusty
Research28 Mar 2025
Nature Physics

Volume: 21, P: 787-798
Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases

Steroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine insecticidal compounds in wild potato or non-bitter SGAs in cultivated tomato.

Pablo D. Cárdenas
Prashant D. Sonawane
Asaph Aharoni
ResearchOpen Access14 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Decorating bacteria with self-assembled synthetic receptors

Cell surface proteins mediate the interactions between cells and their extracellular environment. Here the authors design synthetic biomemetic receptor-like sensors that facilitate programmable interactions between bacteria and their target.

Naama Lahav-Mankovski
Pragati Kishore Prasad
David Margulies
ResearchOpen Access10 Mar 2020
Nature Communications

Volume: 11, P: 1-12
Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila

Applicability of CRISPR-Cas9 for in vivo screening has so far been limited. Here the authors characterize tissue specific CRISPR in the Drosophila mushroom body, generating a library of gRNA-harboring plasmids and fly lines for in vivo screening.

Hagar Meltzer
Efrat Marom
Oren Schuldiner
ResearchOpen Access08 May 2019
Nature Communications

Volume: 10, P: 1-9
Allosteric activation of vinculin by talin

Vinculin binding to talin is a key event in focal adhesion dynamics; yet, how vinculin is activated to recruit actin remains unknown. Here, the authors use a multiscale approach to reveal that talin activates vinculin through an intricate allosteric mechanism tightly regulated by force.

Florian Franz
Rafael Tapia-Rojo
Frauke Gräter
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

Plants contain small levels of cholesterol. Analysis of transcripts, proteins and individual gene silencing in tomato identifies a biosynthetic pathway involving 12 enzymes that is shown to be functional by expression of the full set in Arabidopsis.

Prashant D. Sonawane
Jacob Pollier
Asaph Aharoni
Research22 Dec 2016
Nature Plants

Volume: 3, P: 1-13
Protein recognition by a pattern-generating fluorescent molecular probe

A molecule-sized ‘nose’ capable of producing unique fluorescence signatures for different proteins can detect combinations of biomarkers in biofluids, track several binding interactions simultaneously, and identify isoforms in living cells inaccessible to comparable macroscopic analytical devices.

Zohar Pode
Ronny Peri-Naor
David Margulies
Research16 Oct 2017
Nature Nanotechnology

Volume: 12, P: 1161-1168
Rapid characterization of secreted recombinant proteins by native mass spectrometry

Ben-Nissan et al. present a rapid mass-spectrometry method for characterizing recombinant proteins directly from culture media. They test their method on secreted recombinant proteins from yeast, insect, and human cells, revealing solubility, molecular weight, structure, ligand binding and post-translational modifications.

Gili Ben-Nissan
Shay Vimer
Michal Sharon
ResearchOpen Access03 Dec 2018
Communications Biology

Volume: 1, P: 1-12
Protein production and purification

Susanne Gräslund
Pär Nordlund
Kristin C Gunsalus
Reviews30 Jan 2008
Nature Methods

Volume: 5, P: 135-146
The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition

Shira Kahlon
Dorin Shreibman
Shlomo Elias
CorrespondenceOpen Access24 May 2018
Blood Cancer Journal

Volume: 8, P: 1-4

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Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

Correction: Corrigendum: Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

Enzymes as viscoelastic catalytic machines

Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases

Decorating bacteria with self-assembled synthetic receptors

Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila

Allosteric activation of vinculin by talin

Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

Protein recognition by a pattern-generating fluorescent molecular probe

Rapid characterization of secreted recombinant proteins by native mass spectrometry

Protein production and purification

The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition

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