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Showing 1–7 of 7 results
Advanced filters: Author: Tamara Basta Clear advanced filters

  • Evolution of osmoregulation allowed photosynthetic organisms to transform the whole biosphere. Leveraging high-throughput techniques in the freshwater alga Chlamydomonas reinhardtii, the authors uncover evolutionary conservation and divergence of osmoregulatory pathways within the green lineage.

    • Josep Vilarrasa-Blasi
    • Tamara Vellosillo
    • José R. Dinneny
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Many eukaryotic and archaeal tRNAs carry a modified adenosine (t6A) that is synthesized by the KEOPS complex, which is composed of four subunits. A fifth subunit (Gon7) is found only in fungi and metazoa. Here the authors show that archaea also possess a fifth subunit, which is structurally and functionally similar to eukaryotic Gon7.

    • Marie-Claire Daugeron
    • Sophia Missoury
    • Tamara Basta
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independent functions: controlling neurite outgrowth and synaptic physiology

    • David A. Ruhl
    • Ewa Bomba-Warczak
    • Edwin R. Chapman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Using cryo-electron tomography and single-particle cryo-electron microscopy of functional synaptic vesicles, a V-ATPase–synaptophysin interface was found to regulate synaptic vesicle biogenesis and alter seizure susceptibility.

    • Chuchu Wang
    • Wenhong Jiang
    • Axel T. Brunger
    ResearchOpen Access
    Nature
    Volume: 631, P: 899-904

  • Here the authors reveal the structural basis of how the nicotinic acetylcholine receptor type found on skeletal muscle and in fish electric organs desensitizes in response to agonist and how the arrow poison curare antagonizes the channel by stabilizing a desensitized state.

    • Md. Mahfuzur Rahman
    • Tamara Basta
    • Ryan E. Hibbs
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 386-394

  • Martin Zenker, Corinne Antignac, Friedhelm Hildebrandt and colleagues report that mutations in OSGEP, TP53RK, TPRKB and LAGE3, genes encoding KEOPS-complex subunits, cause Galloway–Mowat syndrome, a recessive disease characterized by early-onset steroid-resistant nephrotic syndrome and microcephaly. Functional studies suggest that the phenotypes result from impaired protein translation, thus leading to endoplasmic reticulum stress and apoptosis.

    • Daniela A Braun
    • Jia Rao
    • Friedhelm Hildebrandt
    Research
    Nature Genetics
    Volume: 49, P: 1529-1538