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Advanced filters: Author: Tamara N. Grund Clear advanced filters

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.

Xu Zhang
Vesselina M. Pearsall
Marissa J. Schafer
ResearchOpen Access27 Sept 2022
Nature Communications

Volume: 13, P: 1-17
Dissecting the conformational complexity and mechanism of a bacterial heme transporter

Characterization of the conformation landscape of the bacterial ABC transporter CydDC reveals that this heterodimeric protein complex is a long-sought heme transporter essential for the functional maturation of bd-type cytochromes.

Di Wu
Ahmad R. Mehdipour
Schara Safarian
ResearchOpen Access24 Apr 2023
Nature Chemical Biology

Volume: 19, P: 992-1003
Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases

Melanie Radloff
Isam Elamri
Schara Safarian
ResearchOpen Access13 Dec 2021
Scientific Reports

Volume: 11, P: 1-9