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Showing 1–2 of 2 results
Advanced filters: Author: Tanes Imamura de Lima Clear advanced filters

  • The authors show that sphingolipids, a class of fat molecules, accumulate in skeletal muscle during aging. They demonstrate that reducing sphingolipids improves age-related fitness in mice by enhancing the myogenic response of muscle and present genetic evidence that these findings may also translate to humans.

    • Pirkka-Pekka Laurila
    • Martin Wohlwend
    • Johan Auwerx
    Research
    Nature Aging
    Volume: 2, P: 1159-1175

  • Ryanodine receptor type 1 (RyR1) are involved in skeletal muscle contraction. Here, the authors show that a transient calcium leak in response to exercise-induced post translational modifications of RyR1 causes mitochondrial remodeling to improve respiration.

    • Nadège Zanou
    • Haikel Dridi
    • Nicolas Place
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19