Organic synthesis relies on the ability to convert simple starting materials into compounds with greater molecular complexity. Here, Trost and co-workers use branched aldehydes as nucleophiles for asymmetric Mannich reactions, and the products of these reactions as electrophiles for the addition of a range of carbon nucleophiles. This provides a simple, stereodivergent route to 1,3-aminoalcohols.
- Barry M. Trost
- Chao-I (Joey) Hung
- Elumalai Gnanamani
