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Showing 1–6 of 6 results
Advanced filters: Author: Tania Auchynnikava Clear advanced filters

  • The cell cycle is regulated by reversible phosphorylations on hundreds of substrates. The authors show that the phosphatases PP2A-B55, PP2A-B56, PP1, and CDC14 target distinct groups of CDK substrates in vivo, and regulate the net phosphorylation timing of these sites at the G2/M transition.

    • Theresa U. Zeisner
    • Tania Auchynnikava
    • Paul Nurse
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is implicated. Here, the authors uncover a set of catalytically dead ‘pseudo’ ubiquitin ligases with possible regulatory roles.

    • Jane Dudley-Fraser
    • Diego Esposito
    • Katrin Rittinger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • In male mouse germline development, the precise DNA methylation of young, active transposons requires a two-step process in which SPIN1 and SPOCD1 mark young LINE1 elements before the piRNA pathway triggers DNA methylation.

    • Madeleine Dias Mirandela
    • Ansgar Zoch
    • Dónal O’Carroll
    ResearchOpen Access
    Nature
    Volume: 634, P: 979-985

  • The PIWI protein MIWI2 counteracts transposon activity by transcriptional silencing in the mammalian germline. Here, the authors show that TEX15 interacts with MIWI2 and is required for piRNA-directed methylation of transposable elements in male germ cells.

    • Theresa Schöpp
    • Ansgar Zoch
    • Dónal O’Carroll
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8