C-type lectin receptor DC-SIGN, expressed on dendritic cells, shapes cytokine production in response to pathogens. Here, the authors show how recognition of fucose-expressing pathogens, Schistosoma mansoni and Helicobacter pylori, by this receptor directs T helper cell type-2 responses via activation of the NF-κB family member Bcl3.
- Sonja I. Gringhuis
- Tanja M. Kaptein
- Teunis B. H. Geijtenbeek
