Chromatin changes are examined in developing primordial germ cells during the time when the cells undergo a reprogramming step involving loss of DNA methylation and parental imprinting. Reprogramming is found to be linked to changes in histone modifications and to histone replacement through the action of histone chaperones. Histone replacement seems to occur subsequent to DNA demethylation.
- Petra Hajkova
- Katia Ancelin
- M. Azim Surani
