The uterine scar that results from cesarean surgery is associated with placenta accreta spectrum (PAS) during subsequent pregnancies. Here, the authors created a model of uterine scar and show that scar matrix activates mechanosensitive ion channel, Piezo1, which causes inflammatory transformation of the decidua, leading to recruitment of extravillous trophoblasts towards the scar, thereby initiating PAS.
- Du Wenqiang
- Ashkan Novin
- Kshitiz
