Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Tanya Svinkina Clear advanced filters

  • Comprehensive protein ubiquitylation profiling by mass spectrometry typically requires large sample amounts, limiting its applicability to tissue samples. Here, the authors present an optimized proteomics method that enables multiplexed ubiquitylome analysis of cells and tumor tissue samples.

    • Namrata D. Udeshi
    • Deepak C. Mani
    • Steven A. Carr
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The network of proteins secreted for interorgan communication is poorly understood. Here, the authors develop a method, based on protein labeling, to study cell-specific secretomes and interorgan protein trafficking, and demonstrate their approach in Drosophila and mouse models.

    • Ilia A. Droujinine
    • Amanda S. Meyer
    • Norbert Perrimon
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy and that the presence of ERG promotes sensitivity to high dose of androgen and SPOP inhibition.

    • Tiziano Bernasocchi
    • Geniver El Tekle
    • Jean-Philippe P. Theurillat
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Lenalidomide, a derivative of thalidomide, is an effective drug for myelodysplastic syndrome; lenalidomide binds the CRL4CRBN E3 ubiquitin ligase and promotes degradation of casein kinase 1a, on which the malignant cells rely for survival.

    • Jan Krönke
    • Emma C. Fink
    • Benjamin L. Ebert
    Research
    Nature
    Volume: 523, P: 183-188

  • Different mutations found in endometrial and prostate tumors affecting the substrate-recognition domain of SPOP, a component of the E3 ubiquitin ligase complex, result in opposing degradation activity of BET proteins and response to BET inhibitors. This work, along with findings by Zhang et al. and Dai et al., highlights the divergent effects of recurrent mutations affecting different residues within the same functional domain of SPOP and provides scientific rationale to guide the administration of BET inhibitors in endometrial and prostate cancer patients harboring SPOP mutations.

    • Hana Janouskova
    • Geniver El Tekle
    • Jean-Philippe P Theurillat
    Research
    Nature Medicine
    Volume: 23, P: 1046-1054

  • Enrichment of biotinylated peptides using an anti-biotin antibody results in substantially improved biotinylation site identifications by mass spectrometry compared to traditional streptavidin-based biotinylated protein enrichment.

    • Namrata D Udeshi
    • Kayvon Pedram
    • Steven A Carr
    Research
    Nature Methods
    Volume: 14, P: 1167-1170